Evidence map›Paper›PMID 28871327›Full record

ArticleEuropean journal of nutrition2018

Micronutrient intake adequacy and depression risk in the SUN cohort study.

Almudena Sánchez-Villegas, Aurora Pérez-Cornago, Itziar Zazpe, Susana Santiago, Francisca Lahortiga, Miguel Angel Martínez-González

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In one paragraph

Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Almudena Sánchez-VillegasNutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, C/Dr. Pasteur s/n, Trasera Hospital Insular, CP 35016, Las Palmas de Gran Canaria, Spain. almudena.sanchez@ulpgc.es.
Aurora Pérez-CornagoCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Itziar ZazpeCiber de Fisiopatología de la Obesidad y Nutrición (CIBER OBN), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Susana SantiagoDepartment of Nutrition and Food Sciences and Physiology, University of Navarra-IDISNA, 31008, Pamplona, Spain.
Francisca LahortigaDepartment of Psychiatry and Medical Psychology, University Clinic of Navarra, 31008, Pamplona, Spain.
Miguel Angel Martínez-GonzálezCiber de Fisiopatología de la Obesidad y Nutrición (CIBER OBN), Instituto de Salud Carlos III, 28029, Madrid, Spain.

Funding

Cancer Research UK 16491
6 · The paper itself

Abstract

purposeThe aim of the study was to prospectively assess the association between micronutrient intake adequacy and risk of depression.

methodsThis dynamic cohort study involves Spanish university graduates (SUN Project). Dietary intake was assessed at baseline and after 10 years of follow-up with a semi-quantitative food frequency questionnaire. Micronutrient intake adequacy for vitamins B1, B2, B3, B6, B12, C, A, D, E, folic acid, zinc, iodine, selenium, iron, calcium, potassium, phosphorus, magnesium and chrome was estimated. Inadequate intake for each nutrient was defined when the intake of the nutrient was below the estimated average requirements (EAR) if available or the adequate intake levels, if EARs were not available. We compared participants with inadequate intake for ≥4 nutrients vs. those with one nutrient. Participants were classified as having incident depression if they had no previous history of depression or antidepressants use at baseline, but they reported during follow-up a new clinical diagnosis of depression by a physician, use of antidepressant drugs, or both. Time-dependent multivariable Cox regression models were fitted.

resultsAfter a median follow-up of 8.5 years, 953 new cases of depression were observed among 13,983 participants. Participants with inadequate intake for ≥4 nutrients showed a significantly higher risk of depression [multivariable hazard ratio (HR) = 1.37; 95% confidence interval (CI) 1.01-1.85]. When the analyses were updated with repeated assessments of intakes, the association was attenuated and it was no longer statistically significant (Multivariable HR = 1.11; 95% CI 0.82-1.51).

conclusionsMicronutrient inadequacy in four or more micronutrients could exert a moderate role in the development of depression.

Indexed as

Nutritional RequirementsAdultCohort StudiesDepressionDietFemaleFolic AcidHumansMaleMicronutrientsNutritional StatusNutrition AssessmentRisk FactorsSpainFolic AcidMicronutrientsCohortDepressionMicronutrientsNutritional adequacy

Identifiers

PMID28871327

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.