ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Excess risk of venous thromboembolism in hip fracture patients and the prognostic impact of comorbidity.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surgical Management of Chronic Subdural Hematoma in Older Adults: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Pooled it
- A decade of increasing complexity in patients sustaining a hip fracture in England, Wales and Northern Ireland: a national cohort study using the National Hip Fracture Database dataset.Age and ageing · 2026Article
- Serious adverse events and mortality among adults with non-surgically treated distal radius fractures- a nationwide population-based cohort study of 184,446 Danish patients.BMC musculoskeletal disorders · 2026Article
- Comparison of clinical outcomes of enoxaparin and aspirin for postoperative venous thromboembolism prophylaxis in hip fractures.Acta orthopaedica et traumatologica turcica · 2026Article
- Impact of Early Surgery on Clinical Outcomes of Super-Aged Patients With Hip Fractures: A Retrospective Propensity Score-Matched Study With 2-Year Follow-Up.Orthopaedic surgery · 2026Article
- Admission deep venous thromboembolism of the lower extremity in patients of subtrochanteric fractures: a retrospective study.BMC musculoskeletal disorders · 2025Article
- Interaction Between Multimorbidity and Hip Fracture Surgery Leads to Excess Risk of Infection: A Danish Registry-Based Cohort Study of 92,599 Patients With Hip Fracture.Clinical epidemiology · 2025Article
- Utilization of the Caprini risk assessment model(RAM) to predict venous thromboembolism after primary hip and knee arthroplasty: an analysis of the Healthcare Cost and Utilization Project(HCUP).Thrombosis journal · 2024Article
- Aspirin is Not for Everyone: Discharge to Non-home Facilities After Total Hip and Knee Arthroplasty Increases Risk of Venous Thromboembolism.Arthroplasty today · 2024Article
- Prevalence of Venous Thromboembolism after Immediate Screening in Hip Fracture Patients.Hip & pelvis · 2024Article
- Antiosteoporosis medications and cardiovascular disease: a population-based nationwide nested case-control study.Frontiers in pharmacology · 2023Article
- Incidence of and risk factors for pre-operative deep venous thrombosis in geriatric intertrochanteric fracture patients.International orthopaedics · 2022Article
- The Interaction Effect Between Previous Stroke and Hip Fracture on Postoperative Mortality: A Nationwide Cohort Study.Clinical epidemiology · 2022Article
- Time for an Update? A Look at Current Guidelines for Venous Thromboembolism Prophylaxis After Hip and Knee Arthroplasty and Hip Fracture.Arthroplasty today · 2021Article
- Incidence and Risk of Venous Thromboembolism in Bisphosphonates and Selective Estrogen Receptor Modulators Treatment in Korea.Journal of Korean medical science · 2021Article
- Development of selective bispecific Wnt mimetics for bone loss and repair.Nature communications · 2021Article
- Mortality and Medical Complications of Subtrochanteric Fracture Fixation.Journal of clinical medicine · 2021Article
- Prevention of Venous Thromboembolism in 2020 and Beyond.Journal of clinical medicine · 2020Review
- Preoperative anemia and total hospitalization time are the independent factors of preoperative deep venous thromboembolism in Chinese elderly undergoing hip surgery.BMC anesthesiology · 2020Article
- The Danish Multidisciplinary Hip Fracture Registry 13-Year Results from a Population-Based Cohort of Hip Fracture Patients.Clinical epidemiology · 2020Article
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4 authors.
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Abstract
Hip fracture patients were at increased excess risk of venous thromboembolism (VTE) up to 1 year following hip fracture. During the first year, interaction between hip fracture and comorbidity was observed among patients with severe and very severe comorbidity.
introductionWe compared the risk of VTE in hip fracture patients with that in the general population. We also examined whether and to what extent the association between hip fracture and VTE varied by comorbidity level.
methodsNationwide cohort study based on Danish health registries, 1995-2015. We identified hip fracture patients (n = 110,563) and sampled a comparison cohort without hip fracture from the general population (n = 552,774). Comorbidity was assessed using the Charlson comorbidity index. We calculated attributable fraction, as the proportion of the VTE rate, among persons exposed to both hip fracture and comorbidity, attributed to exposure interaction.
resultsThe cumulative incidences of VTE were 0.73% within 30 days and 0.83% within 31-365 days among hip fracture patients, and 0.05 and 0.43% in the general population. Adjusted hazard ratios (HRs) of VTE among hip fracture patients were 17.29 [95% confidence interval (CI) 14.74-20.28] during the first 30 days and 2.13 (95% CI 1.95-2.32) during 31-365 days following hip fracture. The relative risks of VTE were 1.03 (95% CI 0.96-1.11) and 1.11 (95% CI 1.00-1.23) after 1-5 years and 6-10 years. During the first 30 days and 31-365 days, 14%/28% of VTE rates and 5%/4% of VTE rates were attributable to the interaction between hip fracture and severe/very severe comorbidity, respectively. Mortality risks within 30 days of VTE were 29.4% in hip fracture and 11.0% in general population cohorts.
conclusionsHip fracture patients were at increased excess risk of VTE up to 1 year following their fracture. During the first year, interaction between hip fracture and comorbidity was observed among patients with severe and very severe comorbidity.
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