ArticleScientific reports2017
Optical-flow based non-invasive analysis of cardiomyocyte contractility.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed.
- Automated fast label-free quantification of cardiomyocyte dynamics with raw holograms for cardiotoxicity screening.Biomedical optics express · 2025Article
- Multidirectional Filamented Light Biofabrication Creates Aligned and Contractile Cardiac Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- PatternJ: an ImageJ toolset for the automated and quantitative analysis of regular spatial patterns found in sarcomeres, axons, somites, and more.Biology open · 2024Article
- scaRNA20 promotes pseudouridylatory modification of small nuclear snRNA U12 and improves cardiomyogenesis.Experimental cell research · 2024Article
- MicroBundleCompute: Automated segmentation, tracking, and analysis of subdomain deformation in cardiac microbundles.PloS one · 2024Article
- Multifocal optical projection microscopy enables label-free 3D measurement of cardiomyocyte cluster contractility.Scientific reports · 2023Article
- Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T.Cell and tissue research · 2023Article
- Contraction pressure analysis using optical imaging in normal and MYBPC3-mutated hiPSC-derived cardiomyocytes grown on matrices with tunable stiffness.Biomaterials and biosystems · 2022Article
- Correlative imaging of the spatio-angular dynamics of biological systems with multimodal instant polarization microscope.Biomedical optics express · 2022Article
- In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events.Human molecular genetics · 2021Article
- Recent Advances in CRISPR/Cas9-Based Genome Editing Tools for Cardiac Diseases.International journal of molecular sciences · 2021Review
- Bioengineered optogenetic model of human neuromuscular junction.Biomaterials · 2021Article
- Dense optical flow software to quantify cellular contractility.Cell reports methods · 2021Article
- Cells/colony motion of oral keratinocytes determined by non-invasive and quantitative measurement using optical flow predicts epithelial regenerative capacity.Scientific reports · 2021Article
- Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis.Scientific reports · 2021Article
- Noonan syndrome patient-specific induced cardiomyocyte model carrying SOS1 gene variant c.1654A>G.Experimental cell research · 2021Article
- Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes.Journal of visualized experiments : JoVE · 2021Article
- SPECC1L-deficient primary mouse embryonic palatal mesenchyme cells show speed and directionality defects.Scientific reports · 2021Article
- Visualization Method for the Cell-Level Vesicle Transport Using Optical Flow and a Diverging Colormap.Sensors (Basel, Switzerland) · 2021Article
- High-resolution integrated piezoresistive sensors for microfluidic monitoring.Lab on a chip · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Characterization of cardiomyocyte beat patterns is needed for quality control of cells intended for surgical injection as well as to establish phenotypes in disease modeling or toxicity studies. Optical-flow based analysis of videomicroscopic recordings offer a manipulation-free and efficient characterization of contractile cycles, an important characteristics of cardiomyocyte phenotype. We demonstrate that by appropriate computational analysis of optical flow data one can identify distinct contractile centers and distinguish active cell contractility from passive elastic tissue deformations. Our proposed convergence measure correlates with myosin IIa immuno-localization and is capable to resolve contractile waves and their synchronization within maturing, unlabeled induced pluripotent stem cell-derived cardiomyocyte cultures.
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Registered trials
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