Evidence map›Paper›PMID 28871194›Full record

ArticleScientific reports2017

Effect of amino acid mutations on the conformational dynamics of amyloidogenic immunoglobulin light-chains: A combined NMR and in silico study.

Sujoy Mukherjee, Simon P Pondaven, Kieran Hand, Jillian Madine, Christopher P Jaroniec

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Sujoy MukherjeeDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, 43210, USA.
Simon P PondavenDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, 43210, USA.
Kieran HandInstitute of Integrative Biology, University of Liverpool, Liverpool, UK.
Jillian MadineInstitute of Integrative Biology, University of Liverpool, Liverpool, UK.
Christopher P JaroniecDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, 43210, USA. jaroniec.1@osu.edu.
The Ohio State University · USUniversity of Liverpool · GBIndian Institute of Chemical Biology · IN

Funding

Molecular Mechanisms of Prion and Amyloid PropagationR01GM094357 · NIGMS · OHIO STATE UNIVERSITY · PI JARONIEC, CHRISTOPHER P · 2011 to 2022
$3.2M
British Heart Foundation FS/12/61/29877NIGMS NIH HHS R01 GM094357
6 · The paper itself

Abstract

The conformational dynamics of a pathogenic κ4 human immunoglobulin light-chain variable domain, SMA, associated with AL amyloidosis, were investigated by

Indexed as

Amino Acid SubstitutionMolecular Dynamics SimulationMutationProtein ConformationCircular DichroismHumansImmunoglobulin Light ChainsMagnetic Resonance SpectroscopyModels, MolecularProtein AggregatesProtein Aggregation, PathologicalProtein BindingStructure-Activity RelationshipImmunoglobulin Light ChainsProtein Aggregates

Identifiers

PMID28871194
PMCPMC5583243
OpenAlexW2750714579

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.