Evidence map›Paper›PMID 28871184›Full record

ArticleScientific reports2017

Motion correction in optoacoustic mesoscopy.

Mathias Schwarz, Natalie Garzorz-Stark, Kilian Eyerich, Juan Aguirre, Vasilis Ntziachristos

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mathias SchwarzChair of Biological Imaging, Technical University of Munich, Ismaningerstr. 22, 81675, Munich, Germany.
Natalie Garzorz-StarkDepartment of dermatology and allergy, Technical University of Munich and ZAUM - Center of allergy and environment, HMGU and Technical University of Munich, Munich, Germany.
Kilian EyerichDepartment of dermatology and allergy, Technical University of Munich and ZAUM - Center of allergy and environment, HMGU and Technical University of Munich, Munich, Germany.
Juan AguirreChair of Biological Imaging, Technical University of Munich, Ismaningerstr. 22, 81675, Munich, Germany.
Vasilis NtziachristosChair of Biological Imaging, Technical University of Munich, Ismaningerstr. 22, 81675, Munich, Germany. v.ntziachristos@tum.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Raster-scan optoacoustic mesoscopy (RSOM), also termed photoacoustic mesoscopy, offers novel insights into vascular morphology and pathophysiological biomarkers of skin inflammation in vivo at depths unattainable by other optical imaging methods. Using ultra-wideband detection and focused ultrasound transducers, RSOM can achieve axial resolution of 4 micron and lateral resolution of 20 micron to depths of several millimeters. However, motion effects may deteriorate performance and reduce the effective resolution. To provide high-quality optoacoustic images in clinical measurements, we developed a motion correction algorithm for RSOM. The algorithm is based on observing disruptions of the ultrasound wave front generated by the vertical movement of the melanin layer at the skin surface. From the disrupted skin surface, a smooth synthetic surface is generated, and the offset between the two surfaces is used to correct for the relative position of the ultrasound detector. We test the algorithm in measurements of healthy and psoriatic human skin and achieve effective resolution up to 5-fold higher than before correction. We discuss the performance of the correction algorithm and its implications in the context of multispectral mesoscopy.

Indexed as

AlgorithmsDiagnostic ImagingHumansMelaninsMotionPhotoacoustic TechniquesPsoriasisSkinTransducersMelanins

Identifiers

PMID28871184
PMCPMC5583247

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.