ArticleScientific reports2017
Late-onset hypersensitivity after a lesion in the ventral posterolateral nucleus of the thalamus: A macaque model of central post-stroke pain.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Optogenetic stimulation attenuates central post-stroke pain via BDNF/TrkB signaling pathway modulation in the ascending pain modulation system.Scientific reports · 2025Article
- Central post-stroke pain: advances in clinical and preclinical research.Stroke and vascular neurology · 2025Review
- Role of Brain Derived Neurotrophic Factor and Related Therapeutic Strategies in Central Post-Stroke Pain.Neurochemical research · 2024Review
- Brain activity changes after high/low frequency stimulation in a nonhuman primate model of central post-stroke pain.Scientific reports · 2024Article
- Prevalence, patterns, and predictors of patient-reported non-motor outcomes at 30 days after acute stroke: Prospective observational hospital cohort study.International journal of stroke : official journal of the International Stroke Society · 2024Observational
- Thermal Grill Illusion in Post-Stroke Patients: Analysis of Clinical Features and Lesion Areas.Journal of pain research · 2023Article
- Modulation of itch and pain signals processing in ventrobasal thalamus by thalamic reticular nucleus.iScience · 2022Article
- The effect and mechanism of exercise for post-stroke pain.Frontiers in molecular neuroscience · 2022Review
- Microglia in the Pathophysiology of Hemorrhagic Stroke and the Relationship Between Microglia and Pain After Stroke: A Narrative Review.Pain and therapy · 2021Review
- Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys.Scientific reports · 2021Article
- Fgr contributes to hemorrhage-induced thalamic pain by activating NF-κB/ERK1/2 pathways.JCI insight · 2020Article
- Shifting brain circuits in pain chronicity.Human brain mapping · 2019Article
- Secondary Pathology of the Thalamus after Focal Cortical Stroke in Rats is not Associated with Thermal or Mechanical Hypersensitivity and is Not Alleviated by Intra-Thalamic Post-Stroke Delivery of Recombinant CDNF or MANF.Cell transplantation · 2019Article
- Review
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4 authors at 2 institutions in 1 country.
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Abstract
Central post-stroke pain (CPSP) can occur as a result of a cerebrovascular accident in the ventral posterolateral nucleus (VPL) of the thalamus. Developing therapeutic interventions for CPSP is difficult because its pathophysiology is unclear. Here we developed and characterized a macaque model of CPSP. The location of the VPL was determined by magnetic resonance imaging (MRI) and extracellular recording of neuronal activity during tactile stimulation, after which a hemorrhagic lesion was induced by injecting collagenase type IV. Histological analysis revealed that most of the lesion was localized within the VPL. Several weeks after the injection, the macaques displayed behavioral changes that were interpreted as reflecting the development of both mechanical allodynia and thermal hyperalgesia. Immunohistochemistry revealed that microglial and astrocytic activation in the perilesional areas lasted at least 3 months after injection. The present model reproduced the symptoms of patients suffering from CPSP, in which both mechanical allodynia and thermal hyperalgesia often develop several weeks after cerebrovascular accident. Further, the long-lasting glial activation revealed here may be characteristic of primate brains following injury. The present model will be useful not only for examining the neurological changes underlying CPSP, but also for testing therapeutic interventions for CPSP.
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