ArticleScientific reports2017
Genetic and non-genetic determinants of thymic epithelial cell number and function.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice.Communications biology · 2022Article
- Article
- Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds.Nature communications · 2020Article
- Retracing the evolutionary emergence of thymopoiesis.Science advances · 2020Article
- Comparative study of computed tomography of normal and lymphoid follicular hyperplasia thymus in myasthenia gravis patients.Experimental and therapeutic medicine · 2019Article
- Fundamental parameters of the developing thymic epithelium in the mouse.Scientific reports · 2018Article
- Thymic stromal cells: Roles in atrophy and age-associated dysfunction of the thymus.Experimental gerontology · 2018Review
- Strain differences in thymic atrophy in rats immunized for EAE correlate with the clinical outcome of immunization.PloS one · 2018Article
- Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity.Frontiers in endocrinology · 2018Review
- Autoimmunity associated with chemically induced thymic dysplasia.International immunology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thymus is the site of T cell development in vertebrates. In general, the output of T cells is determined by the number of thymic epithelial cells (TECs) and their relative thymopoietic activity. Here, we show that the thymopoietic activity of TECs differs dramatically between individual mouse strains. Moreover, in males of some strains, TECs perform better on a per cell basis than their counterparts in females; in other strains, this situation is reversed. Genetic crosses indicate that TEC numbers and thymopoietic capacity are independently controlled. Long-term analysis of functional parameters of TECs after castration provides evidence that the number of Foxn1-expressing TECs directly correlates with thymopoietic activity. Our study highlights potential complications that can arise when comparing parameters of TEC biology across different genetic backgrounds; these could affect the interpretation of the outcomes of interventions aimed at modulating thymic activity in genetically diverse populations, such as humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.