Evidence map›Paper›PMID 28871129›Full record

ArticleScientific reports2017

A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants.

Zhipeng Ma, Peipei Zhu, Meijun Pang, Liwei Guo, Nannan Chang, Jiyuan Zheng, Xiaojun Zhu, Ce Gao, Honghui Huang, Zongbin Cui and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. An animal model recapitulates human hepatic diseases associated withProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Zhipeng MaKey laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Signaling Network, College of Life Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, China.
Peipei ZhuKey laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Signaling Network, College of Life Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, China.
Meijun PangInstitute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100871, China.
Liwei GuoKey laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Signaling Network, College of Life Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, China.
Nannan ChangInstitute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100871, China.
Jiyuan ZhengInstitute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100871, China.
Xiaojun ZhuInstitute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100871, China.
Ce GaoCollege of Animal Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, China.
Honghui HuangKey Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, State Key Laboratory Breeding Base of Eco-Environments and Bio-Resources of the Three Gorges Reservoir Region, School of Life Sciences, Southwest University, 2 Tiansheng Road, Beibei, Chongqing, 400715, China.
Zongbin CuiKey Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, 8 Dong Hu Nan Road, Wuhan, Hubei, 430072, P. R. China.
Jing-Wei XiongInstitute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100871, China. jingwei_xiong@pku.edu.cn.
Jinrong PengCollege of Animal Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, China. pengjr@zju.edu.cn.
Jun ChenKey laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Signaling Network, College of Life Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, China. chenjun2009@zju.edu.cn.
Zhejiang University · CNPeking University · CNInstitute of Hydrobiology · CNSouthwest University · CNState Key Laboratory of Natural and Biomimetic Drugs

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional genetic screens for recessive mutants are inadequate for studying biological processes in the adult vertebrate due to embryonic lethality. Here, we report that a novel inducible mutagenesis system enables to study gene function in both embryonic and adult zebrafish. This system yields genetic mutants with conditional ectopic over- or under-expression of genes in F

Indexed as

MutagenesisAnimalsCloning, MolecularGene Expression Regulation, DevelopmentalGene Transfer TechniquesPhenotypeTranscriptional ActivationZebrafishZebrafish ProteinsZebrafish Proteins

Identifiers

PMID28871129
PMCPMC5583359
OpenAlexW2752219019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.