Evidence map›Paper›PMID 28871128›Full record

ArticleScientific reports2017

Synergistic Effect of BDNF and FGF2 in Efficient Generation of Functional Dopaminergic Neurons from human Mesenchymal Stem Cells.

Manisha Singh, Anupama Kakkar, Rinkey Sharma, O P Kharbanda, Nitika Monga, Manish Kumar, Shantanu Chowdhary, Balram Airan, Sujata Mohanty

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
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  17. Identification of Sodium Transients Through NaFrontiers in cellular neuroscience · 2022
    Article
  18. Article
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  20. Physical Exercise-Induced Myokines in Neurodegenerative Diseases.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Manisha SinghStem Cell Facility (DBT- Centre of Excellence for Stem Cell Research), All India Institute of Medical Sciences, New Delhi, India.
Anupama KakkarStem Cell Facility (DBT- Centre of Excellence for Stem Cell Research), All India Institute of Medical Sciences, New Delhi, India.
Rinkey SharmaStem Cell Facility (DBT- Centre of Excellence for Stem Cell Research), All India Institute of Medical Sciences, New Delhi, India.
O P KharbandaDepartment of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research (CDER), All India Institute of Medical Sciences, New Delhi, India.
Nitika MongaDepartment of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research (CDER), All India Institute of Medical Sciences, New Delhi, India.
Manish KumarInstitute of Genomics and Integrative Biology, New Delhi, India.
Shantanu ChowdharyInstitute of Genomics and Integrative Biology, New Delhi, India.
Balram AiranDepartment of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India.
Sujata MohantyStem Cell Facility (DBT- Centre of Excellence for Stem Cell Research), All India Institute of Medical Sciences, New Delhi, India. drmohantysujata@gmail.com.
All India Institute of Medical Sciences · INInstitute of Genomics and Integrative Biology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To understand the process of neurogenesis, generation of functional dopaminergic (DAergic) neurons from human mesenchymal stem cells (hMSCs) is important. BDNF has been reported to be responsible for inducing neuronal maturation and functionality. Previously, we have reported the efficient generation of neurons from human bone marrow derived MSCs using FGF2 alone. We hypothesize that hMSCs from various tissues [(bone marrow (BM), adipose tissue (AD) and dental pulp (DP)], if treated with BDNF on 9

Indexed as

Adipose TissueBiomarkersBone Marrow CellsBrain-Derived Neurotrophic FactorCell DifferentiationCell LineDental PulpDopaminergic NeuronsDrug SynergismFibroblast Growth Factor 2Gene Expression RegulationGenetic MarkersHumansMesenchymal Stem CellsBiomarkersBrain-Derived Neurotrophic FactorFibroblast Growth Factor 2Genetic Markers

Identifiers

PMID28871128
PMCPMC5583182
OpenAlexW2751229508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.