Evidence map›Paper›PMID 28871097›Full record

ArticleScientific reports2017

Miltefosine Resistant Field Isolate From Indian Kala-Azar Patient Shows Similar Phenotype in Experimental Infection.

Supriya Khanra, Nibedeeta R Sarraf, Anjan K Das, Syamal Roy, Madhumita Manna

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Ethanolic leaf extract ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Supriya KhanraDepartment of Zoology, Barasat Govt. College, 10, K.N.C Road, Kolkata, 700124, India.
Nibedeeta R SarrafDepartment of Zoology, Barasat Govt. College, 10, K.N.C Road, Kolkata, 700124, India.
Anjan K DasDepartment of Pathology, Calcutta National Medical College, 32, Gorachand Road, Kolkata, 700014, India.
Syamal RoyDepartment of Infectious Diseases & Immunology, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata, 700032, India. drsyamalroy@yahoo.com.
Madhumita MannaDepartment of Zoology, Barasat Govt. College, 10, K.N.C Road, Kolkata, 700124, India. madhumita.manna09@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emergence of resistance to drugs used to treat the Indian Kala-azar patients makes control strategy shattered. In this bleak situation, Miltefosine (MIL) was introduced to treat mainly antimonial unresponsive cases. Within years, resistance to MIL has been reported. While checking the MIL sensitivity of the recent KA clinical isolates (n = 26), we came across one isolate which showed four times more EC

Indexed as

Drug ResistanceAntiprotozoal AgentsBiomarkersCytokinesGene Expression RegulationGenes, HelminthHumansLeishmania donovaniLeishmaniasis, VisceralMembrane Potential, MitochondrialNitric OxideParasite LoadParasitic Sensitivity TestsPhenotypePhosphorylcholinePolymorphism, Restriction Fragment LengthAntiprotozoal AgentsBiomarkersCytokinesmiltefosineNitric OxidePhosphorylcholineReactive Oxygen SpeciesRNA, Messenger

Identifiers

PMID28871097
PMCPMC5583325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.