Evidence map›Paper›PMID 28871060›Full record

ArticleEndocrine connections2017

Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary-gonadal axis of primates.

A Daniel Bird, Spencer Greatorex, David Reser, Gareth G Lavery, Timothy J Cole

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine connections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Cooperative care influences genome-wide levels of DNA methylation in nestling chestnut-crowned babblers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

A Daniel BirdDepartment of Biochemistry and Molecular BiologyMonash University, Melbourne, Victoria, Australia.
Spencer GreatorexDepartment of Biochemistry and Molecular BiologyMonash University, Melbourne, Victoria, Australia.
David ReserDepartment of PhysiologyMonash University, Melbourne, Victoria, Australia.
Gareth G LaveryInstitute of Metabolism and Systems Research2nd Floor IBR Tower, University of Birmingham, Birmingham, UK.
Timothy J ColeDepartment of Biochemistry and Molecular BiologyMonash University, Melbourne, Victoria, Australia tim.cole@monash.edu.
Monash University · AUUniversity of Birmingham · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G023468/1
6 · The paper itself

Abstract

Steroid hormones play clinically important and specific regulatory roles in the development, growth, metabolism, reproduction and brain function in human. The type 1 and 2 11-beta hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 2) have key roles in the pre-receptor modification of glucocorticoids allowing aldosterone regulation of blood pressure, control of systemic fluid and electrolyte homeostasis and modulation of integrated metabolism and brain function. Although the activity and function of 11β-HSDs is thought to be understood, there exists an open reading frame for a distinct 11βHSD-like gene;

Indexed as

gonadshydroxysteroid dehydrogenasesovarypituitarytestis

Identifiers

PMID28871060
PMCPMC5592779
OpenAlexW2750785879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.