Evidence map›Paper›PMID 28871047›Full record

ArticleJournal of cell science2017

Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding.

Cynthia Gomes, Seung Joon Lee, Amy S Gardiner, Terika Smith, Pabitra K Sahoo, Priyanka Patel, Elizabeth Thames, Reycel Rodriguez, Ross Taylor, Soonmoon Yoo and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Control of Selective mRNA Translation in Neuronal Subcellular Compartments in Health and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  7. Review
  8. Review
  9. Axonal mRNA localization and translation: local events with broad roles.Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Cynthia GomesDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.ORCID http://orcid.org/0000-0002-5026-0797
Seung Joon LeeDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Amy S GardinerDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Terika SmithDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Pabitra K SahooDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Priyanka PatelDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Elizabeth ThamesDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Reycel RodriguezDepartment of Biochemistry, Medical University of South Carolina, Charleston, SC 29425, USA.
Ross TaylorDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Soonmoon YooNemours Biomedical Research, Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA.
Tilman HeiseDepartment of Biochemistry, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID http://orcid.org/0000-0002-3248-3129
Amar N KarDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Nora Perrone-BizzozeroDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Jeffery L TwissDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA twiss@mailbox.sc.edu.ORCID http://orcid.org/0000-0001-7875-6682
University of South Carolina · USMedical University of South Carolina · USUniversity of New Mexico · USAlfred I. duPont Hospital for Children · US

Funding

Destabilization of axonal mRNAs by KHSRP complexes during axon regenerationR01NS089633 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TWISS, JEFFERY L · 2015 to 2025
$4.1M
Translation during Nerve RegenerationR01NS041596 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TWISS, JEFFERY L · 2001 to 2018
$4.0M
Screen for Inhibitors of La-dependent IRES-mediated Translation in Cancer CellsR01CA172567 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HEISE, TILMAN · 2013 to 2015
$921k
Function of piLRNA/MIWI pathways in neuronal axon growth and regenerationR21NS099959 · NINDS · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI YOO, SOONMOON · 2017 to 2018
$381k
NCI NIH HHS R01 CA172567NINDS NIH HHS R01 NS041596NINDS NIH HHS R01 NS089633NINDS NIH HHS R21 NS099959
6 · The paper itself

Abstract

HuD protein (also known as ELAVL4) has been shown to stabilize mRNAs with AU-rich elements (ARE) in their 3' untranslated regions (UTRs), including

Indexed as

3' Untranslated RegionsAnimalsAxonsBase SequenceBinding, CompetitiveELAV-Like Protein 4Ganglia, SpinalGAP-43 ProteinGene Expression Regulation, DevelopmentalGPI-Linked ProteinsHippocampusMaleMembrane ProteinsNerve Tissue ProteinsNeuronsNeuropeptides3' Untranslated RegionsCpg15 protein, ratElavl4 protein, ratELAV-Like Protein 4GAP-43 ProteinGPI-Linked ProteinsMembrane ProteinsNerve Tissue ProteinsNeuropeptidesNrn1 protein, ratAxonHuDmRNA localizationmRNA transportNrn1RNA-binding protein

Identifiers

PMID28871047
PMCPMC5702053
OpenAlexW2753899031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.