ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Reticulospinal Contributions to Gross Hand Function after Human Spinal Cord Injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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Who cites it
95 citing papers in PubMed, 153 citations in OpenAlex.
- Resistance training tempo selectively modulates corticospinal and reticulospinal excitability in humans.The Journal of physiology · 2026Trial
- Determining the cortical, corticospinal, and reticulospinal responses to metronome-paced and self-paced strength training.European journal of applied physiology · 2026Trial
- Tracking the corticospinal responses to strength training.European journal of applied physiology · 2020Trial
- Neurophysiological and neuromuscular responses associated with the repeated bout effect following eccentric exercise in healthy adults: a systematic review and meta-analysis.European journal of applied physiology · 2026Review
- Descending Brainstem Systems Contribute to Ankle Clonus in Humans with Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Impact of the brainstem in normal and impaired human movement control.The Journal of physiology · 2026Review
- Novel evidence of age-related cortical and subcortical constraints in cross-education.GeroScience · 2026Article
- Age-related differences in corticospinal and reticulospinal adaptations to short-term strength training.European journal of applied physiology · 2026Article
- Spasticity and Abnormal Tone Regulation After Spinal Cord Injury: Mechanisms and the Effects of Neuromodulation.Biomedicines · 2026Review
- What Is the StartReact Effect?Acta physiologica (Oxford, England) · 2026Review
- Enhanced Reticulospinal Output in Subacute Spinal Cord Injury Patients with Spasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Extent of damage to descending output from cortex rather than to specific cortical regions drives the emergence of flexor synergy in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- Evidence for Increased High Alpha Intermuscular Coherence as a Measure of Reticulospinal Motor Drive.The European journal of neuroscience · 2026Article
- Breathing-driven modulation of reticulospinal tract activity.Experimental physiology · 2026Article
- Recovery of Dexterous Motor Control via Non-Monosynaptic Corticospinal Pathways.medRxiv : the preprint server for health sciences · 2026Article
- Transient effects in corticospinal and reticulospinal tract excitability induced by motor skill and isometric resistance training.Brain research · 2026Article
- Lumbar spinal Shox2 interneurons receive monosynaptic excitatory input from the lateral paragigantocellular nucleus in mouse.iScience · 2026Article
- Evolution of object identity information in sensorimotor cortex throughout grasp.Nature communications · 2026Article
- Medullary and C3-C4 propriospinal pathways underlying mammalian forelimb movement control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia.Annals of neurology · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Multiple descending motor pathways likely contribute to the recovery of hand motor function following spinal cord injury (SCI). Reticulospinal neurons project to spinal motor neurons controlling hand muscles and extensively sprout into gray matter structures after SCI; therefore, it has been proposed that the reticulospinal tract is one of the descending motor pathways involved in recovery of hand function after injury. To test this hypothesis, we examined the StartReact response, an involuntary release of a planned movement via a startling stimulus that engages the reticulospinal tract, by measuring reaction times from electromyographic activity in an intrinsic finger muscle during three motor tasks requiring different degrees of hand dexterity: index finger abduction, a precision grip, and a power grip. Males and females with and without incomplete chronic cervical SCI were tested. We found that although SCI participants voluntarily responded to all tasks, reaction times were shorter during a startle cue while performing a power grip but not index finger abduction or precision grip. Control subjects had similarly shorter reaction times during a startle cue in all motor tasks. These results provide the first evidence for a contribution of the reticulospinal tract to hand control in humans with SCI during gross finger manipulations and suggest that this contribution is less pronounced during fine dexterous finger movements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.