Evidence map›Paper›PMID 28870994›Full record

ArticleThe Journal of endocrinology2017

Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia.

Laura E Pascal, Khalid Z Masoodi, June Liu, Xiaonan Qiu, Qiong Song, Yujuan Wang, Yachen Zang, Tiejun Yang, Yao Wang, Lora H Rigatti and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 4 countries.

Laura E PascalDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Khalid Z MasoodiDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
June LiuDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Xiaonan QiuDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Qiong SongDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Yujuan WangDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Yachen ZangDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Tiejun YangDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Yao WangDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Lora H RigattiDivision of Laboratory Animal ResourcesUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Uma ChandranDepartment of Biomedical InformaticsUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Leandro M ColliRibeirao Preto Medical SchoolUniversity of São Paulo, Ribeirão Preto-SP, Brazil.
Ricardo Z N VencioDepartment of Computing and Mathematics FFCLRP-USPUniversity of São Paulo, Ribeirão Preto, Brazil.
Yi LuKey Laboratory of Longevity and Aging-related DiseasesMinistry of Education, China and Center for Translational Medicine Guangxi Medical University, Nanning, Guangxi, China.
Jian ZhangKey Laboratory of Longevity and Aging-related DiseasesMinistry of Education, China and Center for Translational Medicine Guangxi Medical University, Nanning, Guangxi, China.
Zhou WangDepartment of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA wangz2@upmc.edu.
University of Pittsburgh · USJilin University · CNSouthern University of Science and Technology · CNUniversidade de São Paulo · BRGuangxi Medical University · CNHenan Cancer Hospital · CNSher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir · INSoochow University · CN

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
SUPPRESSIVE ROLE OF ANDROGEN RESPONSE GENE CALRETICULIN IN PROSTATE CANCERP50CA090386 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WANG, ZHOU · 2001 to 2013
$25.1M
Targeting FOXA1-downstream pathways: a novel therapeutic strategy for castration-resistant prostate cancerP50CA180995 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABDULKADIR, SARKI A., HUSSAIN, MAHA H · 2015 to 2025
$19.9M
Urologic Training Program for Physicians and ScientistsT32DK007774 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, ZHOU · 1999 to 2014
$2.3M
Roles of EAF2 in androgen action in the prostateR01CA186780 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, ZHOU · 2014 to 2018
$1.9M
Cellular mechanisms of androgen action and androgen-response gene EAF2 in prostate cancerR50CA211242 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PASCAL, LAURA ELLEN · 2016 to 2020
$575k
NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA090386NCI NIH HHS P50 CA180995NCI NIH HHS R01 CA186780NCI NIH HHS R50 CA211242NIDDK NIH HHS T32 DK007774
6 · The paper itself

Abstract

Elongation factor, RNA polymerase II, 2 (ELL2) is an RNA Pol II elongation factor with functional properties similar to ELL that can interact with the prostate tumor suppressor EAF2. In the prostate,

Indexed as

AnimalsCell Line, TumorEpithelial CellsGene Expression Regulation, NeoplasticHumansMaleMiceMice, KnockoutProstatic NeoplasmsProtein Array AnalysisReproducibility of ResultsTranscriptional Elongation FactorsELL2 protein, humanELL2 protein, mouseTranscriptional Elongation FactorsEAF2ELL2HIF1αprostate cancerprostatic intraepithelial neoplasia

Identifiers

PMID28870994
PMCPMC5679084
OpenAlexW2752776294

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.