Evidence map›Paper›PMID 28870991›Full record

ArticleDevelopment (Cambridge, England)2017

The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis.

Kelly J Soady, Giusy Tornillo, Howard Kendrick, Valerie Meniel, Daria Olijnyk-Dallis, Joanna S Morris, Torsten Stein, Barry A Gusterson, Clare M Isacke, Matthew J Smalley

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Effects ofFrontiers in veterinary science · 2025
    Article
  3. Review
  4. Hsa_circ_0129047 sponges miR-665 to attenuate lung adenocarcinoma progression by upregulating protein tyrosine phosphatase receptor type B.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Article
  5. Article
  6. Comparative genomics provides insights into the aquatic adaptations of mammals.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. All Good Things Must End: Termination of Receptor Tyrosine Kinase Signal.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Mammary Organoids and 3D Cell Cultures: Old Dogs with New Tricks.Journal of mammary gland biology and neoplasia · 2020
    Review
  10. Article
  11. Lineage-negative lymphoma with a helper innate lymphoid cell phenotype.Virchows Archiv : an international journal of pathology · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kelly J SoadyDivision of Breast Cancer Research, Breast Cancer Now Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.ORCID 0000-0002-8274-7831
Giusy TornilloEuropean Cancer Stem Cell Research Institute and Cardiff School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.
Howard KendrickEuropean Cancer Stem Cell Research Institute and Cardiff School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.
Valerie MenielEuropean Cancer Stem Cell Research Institute and Cardiff School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.
Daria Olijnyk-DallisInstitute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Joanna S MorrisSchool of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK.
Torsten SteinInstitute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Barry A GustersonInstitute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Clare M IsackeDivision of Breast Cancer Research, Breast Cancer Now Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Matthew J SmalleyEuropean Cancer Stem Cell Research Institute and Cardiff School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK SmalleyMJ@Cardiff.ac.uk.ORCID 0000-0001-9540-1146
Cardiff University · GBUniversity of Glasgow · GBInstitute of Cancer Research · GB

Funding

Breast Cancer Now 2012MAYPR076Cancer Research UK 15938Cancer Research UK A15938
6 · The paper itself

Abstract

PTPRB is a transmembrane protein tyrosine phosphatase known to regulate blood vessel remodelling and angiogenesis. Here, we demonstrate that PTPRB negatively regulates branching morphogenesis in the mouse mammary epithelium. We show that

Indexed as

MorphogenesisAnimalsBody PatterningEpithelial CellsExtracellular Signal-Regulated MAP KinasesFemaleFibroblast Growth Factor 2Gene Expression ProfilingGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsMammary Glands, AnimalMiceNeovascularization, PhysiologicOligonucleotide Array Sequence AnalysisOrganoidsPhosphorylationExtracellular Signal-Regulated MAP KinasesFibroblast Growth Factor 2Green Fluorescent ProteinsPtprb protein, mouseReceptor-Like Protein Tyrosine Phosphatases, Class 3Receptors, EstrogenReceptors, Fibroblast Growth FactorRNA, Small InterferingBranching morphogenesisFGFR2Mammary stem cellsMousePTPRBTerminal end bud gene expression

Identifiers

PMID28870991
PMCPMC6126639
OpenAlexW2752434883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.