Evidence map›Paper›PMID 28870443›Full record

ReviewPhysiology & behavior2018

Light at night as an environmental endocrine disruptor.

Kathryn L G Russart, Randy J Nelson

Abstract readReview
In one paragraph

Review in Physiology & behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 168 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effects of a violet-excitation light-emitting diode on melatonin secretion and sleepiness: preliminary findings from a randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Trial
  4. Article
  5. Influence of Artificial Light at Night on Thyroid Gland Histology inAnimals : an open access journal from MDPI · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. The Effects of Light on Vertebrate Welfare: A Review.Animals : an open access journal from MDPI · 2025
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Thyroid hormone links environmental signals to DNA methylation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kathryn L G RussartDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: kathryn.russart@osumc.edu.
Randy J NelsonDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
The Ohio State University Wexner Medical Center · US

Funding

Adverse Consequences of Light at Night for Cerebral IschemiaR01NS092388 · NINDS · WEST VIRGINIA UNIVERSITY · PI DEVRIES, ANNE COURTNEY, NELSON, RANDY J. · 2015 to 2019
$2.3M
Dim light at night alters pancreatic cell signaling and predisposes to pancreatic adenocarcinomaR21CA202745 · NCI · OHIO STATE UNIVERSITY · PI CHBEIR, SOUHAD · 2016 to 2017
$368k
NCI NIH HHS R21 CA202745NINDS NIH HHS R01 NS092388
6 · The paper itself

Abstract

Environmental endocrine disruptors (EEDs) are often consequences of human activity; however, the effects of EEDs are not limited to humans. A primary focus over the past ∼30years has been on chemical EEDs, but the repercussions of non-chemical EEDs, such as artificial light at night (LAN), are of increasing interest. The sensitivity of the circadian system to light and the influence of circadian organization on overall physiology and behavior make the system a target for disruption with widespread effects. Indeed, there is increasing evidence for a role of LAN in human health, including disruption of circadian regulation and melatonin signaling, metabolic dysregulation, cancer risk, and disruption of other hormonally-driven systems. These effects are not limited to humans; domesticated animals as well as wildlife are also exposed to LAN, and at risk for disrupted circadian rhythms. Here, we review data that support the role of LAN as an endocrine disruptor in humans to be considered in treatments and lifestyle suggestions. We also present the effects of LAN in other animals, and discuss the potential for ecosystem-wide effects of artificial LAN. This can inform decisions in agricultural practices and urban lighting decisions to avoid unintended outcomes.

Indexed as

AnimalsEndocrine DisruptorsHumansLightingEndocrine DisruptorsCancerCircadian rhythmsEnvironmental endocrine disruptorLight at nightMetabolismWildlife

Identifiers

PMID28870443
PMCPMC5839924
OpenAlexW2752660514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.