ArticleeLife2017
Attenuation of dopamine-modulated prefrontal value signals underlies probabilistic reward learning deficits in old age.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
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- Anxiety associated with perceived uncontrollable stress enhances expectations of environmental volatility and impairs reward learning.Scientific reports · 2023Article
- Effects of Adult Age and Functioning of the Locus Coeruleus Norepinephrinergic System on Reward-Based Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Effects of positive and negative social feedback on motivation, evaluative learning, and socio-emotional processing.NPJ science of learning · 2023Article
- Trait anxiety is associated with hidden state inference during aversive reversal learning.Nature communications · 2023Article
- Modulation of Motor Vigor by Expectation of Reward Probability Trial-by-Trial Is Preserved in Healthy Ageing and Parkinson's Disease Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Multivariate associations between dopamine receptor availability and risky investment decision-making across adulthood.Cerebral cortex communications · 2023Article
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- Impaired learning to dissociate advantageous and disadvantageous risky choices in adolescents.Scientific reports · 2022Article
- Multi-scale neural decoding and analysis.Journal of neural engineering · 2021Review
- Involvement of the dopaminergic system in the reward-related behavior of pregabalin.Scientific reports · 2021Article
- Corticostriatal White Matter Integrity and Dopamine D1 Receptor Availability Predict Age Differences in Prefrontal Value Signaling during Reward Learning.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Motivation and sensitivity to monetary reward in late-life insomnia: moderating role of sex and the inflammatory marker CRP.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Associations between aversive learning processes and transdiagnostic psychiatric symptoms in a general population sample.Nature communications · 2020Article
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- Variability in Action Selection Relates to Striatal Dopamine 2/3 Receptor Availability in Humans: A PET Neuroimaging Study Using Reinforcement Learning and Active Inference Models.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probabilistic reward learning is characterised by individual differences that become acute in aging. This may be due to age-related dopamine (DA) decline affecting neural processing in striatum, prefrontal cortex, or both. We examined this by administering a probabilistic reward learning task to younger and older adults, and combining computational modelling of behaviour, fMRI and PET measurements of DA D1 availability. We found that anticipatory value signals in ventromedial prefrontal cortex (vmPFC) were attenuated in older adults. The strength of this signal predicted performance beyond age and was modulated by D1 availability in nucleus accumbens. These results uncover that a value-anticipation mechanism in vmPFC declines in aging, and that this mechanism is associated with DA D1 receptor availability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.