Evidence map›Paper›PMID 28870263›Full record

Trial reportTrials2017

Effect of maternal vitamin D

Christopher R Sudfeld, Karim P Manji, Christopher P Duggan, Said Aboud, Alfa Muhihi, David M Sando, Fadhlun M Alwy Al-Beity, Molin Wang, Wafaie W Fawzi

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02305927 (Trial of Vitamin D in HIV Progression, Birth Outcomes, and Child Health), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02305927 phase3completednot on this map

Trial of Vitamin D in HIV Progression, Birth Outcomes, and Child Health

TypeinterventionalSponsorWafaie FawziRan2015 to 2019Enrolled2,300ConditionsHIVArmsVitamin D3 (cholecalciferol), Placebo
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Christopher R SudfeldDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Building I Room 1103C, Boston, MA, 02115, USA. csudfeld@hsph.harvard.edu.
Karim P ManjiDepartment of Pediatrics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Christopher P DugganDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Building I Room 1103C, Boston, MA, 02115, USA.
Said AboudDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Alfa MuhihiManagement and Development for Health, Dar es Salaam, Tanzania.
David M SandoDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Building I Room 1103C, Boston, MA, 02115, USA.
Fadhlun M Alwy Al-BeityDepartment of Obstetrics and Gynecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Molin WangDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Wafaie W FawziDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Building I Room 1103C, Boston, MA, 02115, USA.
Harvard University · USManagement and Development for Health · TZHarvard Global Health Institute · USMuhimbili University of Health and Allied Sciences · TZ

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Trial of Vitamin D in Maternal HIV Progression and Child HealthR01HD083113 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W, SUDFELD, CHRISTOPHER · 2014 to 2018
$2.4M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
NICHD NIH HHS R01 HD083113NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

backgroundVitamin D has significant immunomodulatory effects on both adaptive and innate immune responses. Observational studies indicate that adults infected with HIV with low vitamin D status may be at increased risk of mortality, pulmonary tuberculosis, and HIV disease progression. Growing observational evidence also suggests that low vitamin D status in pregnancy may increase the risk of adverse birth and infant health outcomes. As a result, antiretroviral therapy (ART) adjunct vitamin D METHODS/

designThe Trial of Vitamins-5 (ToV5) is an individually randomized, double-blind, placebo-controlled trial of maternal vitamin D DISCUSSION: The ToV5 will provide causal evidence on the effect of vitamin D

trial registrationClinicalTrials.gov identifier: NCT02305927 . Registered on 29 October 2014.

Indexed as

Age FactorsAnti-HIV AgentsBirth WeightChild DevelopmentCholecalciferolClinical ProtocolsDietary SupplementsDouble-Blind MethodFemaleHIV InfectionsHumansInfantInfant, NewbornInfant, Small for Gestational AgeMaternal HealthMaternal Health ServicesAnti-HIV AgentsCholecalciferol

Identifiers

PMID28870263
PMCPMC5584035
OpenAlexW2753659921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.