Evidence map›Paper›PMID 28870210›Full record

ArticleJournal of nanobiotechnology2017

Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots.

Xin Yan, Yan Zhao, Juan Luo, Wei Xiong, Xiaoman Liu, Jinjun Cheng, Yongzhi Wang, Meiling Zhang, Huihua Qu

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 104 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xin YanSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Yan ZhaoSchool of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Juan LuoSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Wei XiongSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Xiaoman LiuSchool of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Jinjun ChengSchool of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Yongzhi WangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Meiling ZhangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Huihua QuCenter of Scientific Experiment, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing, 100029, China. quhuihuadr@163.com.
Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPollen Typhae Carbonisata (PTC) is a type of calcined herb drug that has been used as a hemostatic medicine to promote hemostasis for thousands of years. In this study, we discovered and separated novel water-soluble carbon quantum dots (CQDs, named PTC-CQDs) from aqueous extracts of PTC. These PTC-CDs were characterized using transmission electron microscopy (TEM) and high-resolution TEM, as well as Fourier transform infrared, ultraviolet-visible, and fluorescence spectroscopy. Then, we assessed the anti-hemorrhagic effects and related hemostatic mechanisms of the obtained PTC-CQDs.

resultsThe PTC-CQDs separated from PTC are spherical, monodisperse, and have a narrow size distribution between 2 and 8 nm. In the pharmacology experiment, remarkable anti-hemorrhage effects of PTC-CQDs were revealed. Additionally, the rats showed a profound decrease in activated partial thromboplastin time and increase in fibrinogen and PLT after PTC-CQDs treatment.

conclusionsThese results indicated the explicit hemostasis effect of PTC-CQDs, which not only provided a new idea for the material research of PTC, but have also provided new insights into potential biomedical and healthcare applications of CQDs in the field of haemorrhage control and laid a solid foundation for future drug discovery.

Indexed as

PollenTyphaceaeAnimalsBlood CoagulationCarbonCharcoalDrugs, Chinese HerbalHemorrhageHemostaticsMaleMiceQuantum DotsRatsRats, Sprague-DawleyCarbonCharcoalDrugs, Chinese HerbalHemostaticsCarbon quantum dotsCharcoal drugDrug discoveryHemostasisPollen Typhae Carbonisata

Identifiers

PMID28870210
PMCPMC5584017
OpenAlexW2753332476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.