Evidence map›Paper›PMID 28870151›Full record

Observational studyBMC nephrology2017

Progression of arterial stiffness is associated with changes in bone mineral markers in advanced CKD.

Rathika Krishnasamy, Sven-Jean Tan, Carmel M Hawley, David W Johnson, Tony Stanton, Kevin Lee, David W Mudge, Scott Campbell, Grahame J Elder, Nigel D Toussaint and 1 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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  13. The direct effect of fibroblast growth factor 23 on vascular smooth muscle cell phenotype and function.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Rathika KrishnasamyDepartment of Nephrology, Sunshine Coast University Hospital, PO Box 5340, Sunshine Coast, Birtinya, MC QLD, 4560, Australia. Rathika.Krishnasamy@health.qld.gov.au.ORCID http://orcid.org/0000-0001-6974-7880
Sven-Jean TanDepartment of Nephrology, The Royal Melbourne Hospital (RMH), Melbourne, VIC, Australia.
Carmel M HawleyFaculty of Medicine, The University of Queensland, Brisbane, Australia.
David W JohnsonFaculty of Medicine, The University of Queensland, Brisbane, Australia.
Tony StantonFaculty of Medicine, The University of Queensland, Brisbane, Australia.
Kevin LeeDepartment of Radiology, Princess Alexandra Hospital, Brisbane, Australia.
David W MudgeFaculty of Medicine, The University of Queensland, Brisbane, Australia.
Scott CampbellFaculty of Medicine, The University of Queensland, Brisbane, Australia.
Grahame J ElderDepartment of Renal Medicine, Westmead Hospital, Sydney, Australia.
Nigel D ToussaintDepartment of Nephrology, The Royal Melbourne Hospital (RMH), Melbourne, VIC, Australia.
Nicole M IsbelFaculty of Medicine, The University of Queensland, Brisbane, Australia.
The University of Queensland · AUThe Royal Melbourne Hospital · AUTranslational Research Institute · AUGarvan Institute of Medical Research · AUPrincess Alexandra Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibroblast growth factor 23 (FGF23) and soluble α-klotho (sKl).

methodsIn this prospective, single-center, observational study, arterial stiffness [measured by pulse wave velocity (PWV)] and hormones influencing mineral homeostasis, including serum FGF23 and sKl, were compared between non-dialysis CKD stages 4/5 and healthy controls at baseline and 12 months (12 m). Abdominal aortic calcification (AAC) was quantitated using lateral lumbar radiography at baseline.

resultsForty patients with CKD [mean estimated glomerular filtration rate (eGFR) 19.5 ± 6.7 mL/min/1.73m

conclusionsArterial stiffness and serum FGF23, both of which are associated with increased cardiovascular risk, increased over one year in individuals with CKD. Additionally, a significant association was found between serum FGF23 and arterial calcification and stiffness. Larger clinical studies and further experimental work are warranted to delineate the temporal relationship as well as the pathological mechanisms linking FGF23 and vascular disease.

Indexed as

Disease ProgressionAgedBiomarkersBone DensityFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsFollow-Up StudiesGlomerular Filtration RateHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesPulse Wave AnalysisRenal Insufficiency, ChronicBiomarkersFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsAortic calcificationArterial stiffnessChronic kidney diseaseFibroblast growth factor 23Soluble klotho

Identifiers

PMID28870151
PMCPMC5584006
OpenAlexW2752404219

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.