Trial reportAnnals of internal medicine2017
Effects of Intensive Systolic Blood Pressure Control on Kidney and Cardiovascular Outcomes in Persons Without Kidney Disease: A Secondary Analysis of a Randomized Trial.
Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Annals of internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01206062 (Systolic Blood Pressure Intervention Trial), which is not on this map. Cited by 61 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Systolic Blood Pressure Intervention Trial
Who cites it
61 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effect of intensive versus standard blood pressure control on cardiovascular outcomes in adult patients with hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Pooled it
- Systolic blood pressure targets below 120 mm Hg are associated with reduced mortality: A meta-analysis.Journal of internal medicine · 2025Pooled it
- Intensive Blood Pressure Treatment Goals: Evidence for Cardiovascular Protection From Observational Studies and Clinical Trials.American journal of hypertension · 2022Pooled it
- Serious adverse events in patients with target-oriented blood pressure management: a systematic review.Journal of hypertension · 2019Pooled it
- Systolic blood pressure time-in-target range and kidney outcomes in patients with hypertension: Findings from the STEP trial.Chinese medical journal · 2026Trial
- Low Achieved Systolic Blood Pressure Related to Kidney Protection in Diabetic and Non-Diabetic High-Risk Hypertensive Patients.American journal of hypertension · 2025Trial
- Intensive Systolic Blood Pressure Reduction and Kidney and Cardiovascular Outcomes: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2025Trial
- Association of baseline eGFR and incident heart failure on patients receiving intensive blood pressure treatment.ESC heart failure · 2025Trial
- Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Trial
- Final Report of a Trial of Intensive versus Standard Blood-Pressure Control.The New England journal of medicine · 2021Trial
- Modification of the effects of intensive systolic blood pressure control on kidney outcomes by baseline body mass index.Nephrology (Carlton, Vic.) · 2021Trial
- Heterogeneity of treatment effect in SPRINT by age and baseline comorbidities: The greatest impact of intensive blood pressure treatment is observed among younger patients without CKD or CVD and in older patients with CKD or CVD.Journal of clinical hypertension (Greenwich, Conn.) · 2020Trial
- Implications of Early Decline in eGFR due to Intensive BP Control for Cardiovascular Outcomes in SPRINT.Journal of the American Society of Nephrology : JASN · 2019Trial
- Effect of Intensive Blood Pressure Lowering on Kidney Tubule Injury: Findings From the ACCORD Trial Study Participants.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Trial
- Trial
- Gender, blood pressure, and cardiovascular and renal outcomes in adults with hypertension from the Systolic Blood Pressure Intervention Trial.Journal of hypertension · 2018Trial
- Intensive vs Standard Blood Pressure Lowering in People With and Without Chronic Kidney Disease: A Systematic Review and Meta-Analysis.JAMA cardiology · 2026Article
- Effects of intensive blood pressure control on cardio-kidney outcomes by KDIGO risk categories: a Post Hoc analysis of ACCORD-BP and SPRINT trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Incident Hypertension in Young Adults With a Mild Estimated Glomerular Filtration Rate Reduction.Journal of the American Heart Association · 2026Article
- Blood pressure and renal function decline in apparently healthy adults: the tehran lipid and glucose study.Journal of human hypertension · 2026Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
21 authors.
Srinivasan BeddhuFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Michael V RoccoFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Robert TotoFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Timothy E CravenFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Tom GreeneFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Udayan BhattFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Alfred K CheungFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Debbie CohenFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Barry I FreedmanFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Amret T HawfieldFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Anthony A KilleenFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Paul L KimmelFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
James LashFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Vasilios PapademetriouFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Mahboob RahmanFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Anjay RastogiFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Karen ServillaFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Raymond R TownsendFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Barry WallFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Paul K WheltonFrom University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
SPRINT Research Group
Funding
INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4MUniversity of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MMichigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUBENFIRE, MELVYN · 1985 to 2007
$40.8MInstitutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9MTufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4MUniversity of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025771 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2008 to 2011
$17.6MTUFTS CLINICAL AND TRANSLATION SCIENCE INSTITUTE (UL1): BPCAUL1RR025752 · NCRR · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2008 to 2011
$17.6MClinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7MNCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000050NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000073NCATS NIH HHS UL1 TR000075NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001064NCRR NIH HHS M01 RR000042NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR025752NCRR NIH HHS UL1 RR025755NCRR NIH HHS UL1 RR025771NHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNIDDK NIH HHS R01 DK091437NIDDK NIH HHS R21 DK106574NIGMS NIH HHS P30 GM103337
Abstract
backgroundThe public health significance of the reported higher incidence of chronic kidney disease (CKD) with intensive systolic blood pressure (SBP) lowering is unclear.
objectiveTo examine the effects of intensive SBP lowering on kidney and cardiovascular outcomes and contrast its apparent beneficial and adverse effects.
designSubgroup analyses of SPRINT (Systolic Blood Pressure Intervention Trial). (ClinicalTrials.gov: NCT01206062).
settingAdults with high blood pressure and elevated cardiovascular risk.
participants6662 participants with a baseline estimated glomerular filtration rate (eGFR) of at least 60 mL/min/1.73 m2.
interventionRandom assignment to an intensive or standard SBP goal (120 or 140 mm Hg, respectively). MEASUREMENTS: Differences in mean eGFR during follow-up (estimated with a linear mixed-effects model), prespecified incident CKD (defined as a >30% decrease in eGFR to a value <60 mL/min/1.73 m2), and a composite of all-cause death or cardiovascular event, with surveillance every 3 months.
resultsThe difference in adjusted mean eGFR between the intensive and standard groups was -3.32 mL/min/1.73 m2 (95% CI, -3.90 to -2.74 mL/min/1.73 m2) at 6 months, was -4.50 mL/min/1.73 m2 (CI, -5.16 to -3.85 mL/min/1.73 m2) at 18 months, and remained relatively stable thereafter. An incident CKD event occurred in 3.7% of participants in the intensive group and 1.0% in the standard group at 3-year follow-up, with a hazard ratio of 3.54 (CI, 2.50 to 5.02). The corresponding percentages for the composite of death or cardiovascular event were 4.9% and 7.1% at 3-year follow-up, with a hazard ratio of 0.71 (CI, 0.59 to 0.86). LIMITATION: Long-term data were lacking.
conclusionIntensive SBP lowering increased risk for incident CKD events, but this was outweighed by cardiovascular and all-cause mortality benefits. PRIMARY FUNDING SOURCE: National Institutes of Health.
Indexed as
AgedAntihypertensive AgentsCardiovascular DiseasesCause of DeathFollow-Up StudiesGlomerular Filtration RateHumansHypertensionIncidenceRenal Insufficiency, ChronicRisk FactorsAntihypertensive Agents
Identifiers
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Registered trials
NCT01206062ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.