Leukaemia: Vitamin C regulates stem cells and cancer.

Peter G Miller, Benjamin L Ebert

Abstract readComment

In one paragraph

Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

1.3field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

Biodistribution and radiation dosimetry in cancer patients of the ascorbic acid analogue 6-Deoxy-6-[European journal of nuclear medicine and molecular imaging · 2023
Article
Vitamin C: From nutrition to oxygen sensing and epigenetics.Redox biology · 2023
Article
Toward Achieving Rapid Estimation of Vitamin C in Citrus Peels by NIR Spectra Coupled with a Linear Algorithm.Molecules (Basel, Switzerland) · 2023
Article
Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans.Nature communications · 2019
Article
Chemical composition, antioxidant, anti-inflammatory, and cytotoxic activities of Opuntia stricta cladodes.PloS one · 2019
Article
Ascorbic acid metabolism and functions: A comparison of plants and mammals.Free radical biology & medicine · 2018
Review
Association of Leukemia Target GenesCancer genomics & proteomics
Article

4 · The record

Corrections and comments

Comment on
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.2017
Comment on
Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.2017

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peter G MillerDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA, in the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Benjamin L EbertDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA, in the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Harvard University · US

Funding

SYNTHESIS OF MATERIALS WITH PHYSIOLOGICAL PROPERTIESR01GM038627 · NIGMS · YALE UNIVERSITY · PI SCHREIBER, STUART L · 1987 to 2017

$10.5M

Training Program in Molecular HematologyT32HL116324 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI NANCY BERLINER · 2013 to 2026

$7.4M

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Ascorbic AcidLeukemiaHumansNeoplasmsNeoplastic Stem CellsStem CellsVitaminsAscorbic AcidVitamins

Identifiers

PMID28869971

DOI10.1038/nature23548

OpenAlexW2752946756

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.