ArticleCancer science2017
Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14.
Article in Cancer science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Single-Cell Analysis Identified a Recurrent Malignant-Associated Transcriptional State in Colorectal Cancer.Cancer science · 2026Article
- Examining the Factors That Affect the Diagnosis of Patients with Positive Fecal Occult Blood Test Results.International journal of environmental research and public health · 2022Article
- Repurposing non-invasive prenatal testing data: Population study of single nucleotide variants associated with colorectal cancer and Lynch syndrome.Oncology letters · 2021Article
- Association of four genetic variants with colorectal cancer in Kazakhstan population.Oncotarget · 2021Article
- Evaluation of common genetic variants in vitamin E-related pathway genes and colorectal cancer susceptibility.Archives of toxicology · 2021Article
- Factors affecting the follow-up time after a positive result in the fecal occult blood test.PloS one · 2021Article
- GTF2IRD1 on chromosome 7 is a novel oncogene regulating the tumor-suppressor gene TGFβR2 in colorectal cancer.Cancer science · 2020Article
- Trends in and Predictions of Colorectal Cancer Incidence and Mortality in China From 1990 to 2025.Frontiers in oncology · 2019Article
- Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14.Cancer science · 2017Article
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Authors and funding
19 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies are a powerful tool for searching for disease susceptibility loci. Several studies identifying single nucleotide polymorphisms (SNP) connected intimately to the onset of colorectal cancer (CRC) have been published, but there are few reports of genome-wide association studies in Japan. To identify genetic variants that modify the risk of CRC oncogenesis, especially in the Japanese population, we performed a multi-stage genome-wide association study using a large number of samples: 1846 CRC cases and 2675 controls. We identified 4 SNP (rs7912831, rs4749812, rs7898455 and rs10905453) in chromosome region 10p14 associated with CRC; however, there are no coding or non-coding genes within this region of fairly extensive linkage disequilibrium (a 500-kb block) on 10p14. Our study revealed that the 10p14 locus is significantly correlated with susceptibility to CRC in the Japanese population, in accordance with the results of multiple studies in other races.
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