ArticleMedical science monitor : international medical journal of experimental and clinical research2017
The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Posterior Olecranon Fracture Dislocations in Adults: A Systematic Review.Orthopaedic surgery · 2023Pooled it
- Irisin and its role in fracture healing: A comparative study with hyaluronic acid and platelet-rich plasma in a rat model.Joint diseases and related surgery · 2025Article
- Displaced Femoral Neck Fractures Treated with Percutaneous Compression Plates in Elderly Individuals: An Effect Analysis Based on Imaging.Current medical imaging · 2025Article
- Poor radiological outcomes and associated factors among tibial shaft fracture patients treated with intramedullary nail fixation at Addis Ababa Burn, Emergency and Trauma Hospital, Ethiopia.Frontiers in surgery · 2025Article
- Irisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology.International journal of molecular sciences · 2024Review
- Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma.JBMR plus · 2024Article
- Calcaneal distraction vs. cast immobilization for the preoperative treatment of patients with Danis-Weber type C ankle fractures: a case-control study.Frontiers in surgery · 2024Article
- Management of comminuted patellar fractures using suture reduction technique combined with the modified Kirschner-wire tension band.BMC surgery · 2023Article
- Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration.International journal of molecular sciences · 2023Review
- Role of irisin in bone diseases.Frontiers in endocrinology · 2023Review
- Irisin and Bone in Sickness and in Health: A Narrative Review of the Literature.Journal of clinical medicine · 2022Review
- Irisin promotes fracture healing by improving osteogenesis and angiogenesis.Journal of orthopaedic translation · 2022Article
- The Surgical Timing and Complications of Rib Fixation for Rib Fractures in Geriatric Patients.Journal of personalized medicine · 2022Article
- Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations.International journal of molecular sciences · 2022Article
- Review
- Ethical Dilemmas with Regard to Elderly Patients with Hip Fracture: The Problem of Nonagenarians and Centenarians.Journal of clinical medicine · 2022Article
- FNDC5/Irisin: Physiology and Pathophysiology.Molecules (Basel, Switzerland) · 2022Review
- Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up.Medicine · 2022Article
- Contralateral non-simultaneous proximal femoral fractures in patients over 65 years old.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Article
- Global Research Status and Trends of Femoral Neck Fracture Over the Past 27 Years: A Historical Review and Bibliometric Analysis.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Whether or not there is a relationship between the newly-discovered irisin hormone and bone healing is not yet known. The aim of this study was to investigate what effect irisin hormone has on the bone healing process. MATERIAL AND METHODS The study included 21 adult patients with a diagnosed fracture of the lower extremity (femur or tibia). Informed consent was obtained from all the patients. A total of four venous blood samples were taken from the patients: before fracture stabilization, then postoperatively on days 1, 10, and 60. In patients with femoral neck fracture who had hip prosthesis applied, bone tissue samples were taken from the removed femur head and irisin was determined immunohistochemically in muscle biopsies taken from the same patients. RESULTS In analysis, it was revealed that the mean value of irisin 60 days after operation is significantly higher than the values of irisin before operation, 1 day after operation, and 15 day after operation (p<0.001, p<0.001, p<0.001, respectively). Intense staining was observed in compact bone tissue, muscle tissue, and in hypertrophic vascular endothelium within the Havers canal. CONCLUSIONS The level of irisin hormone increased in the bone union process and affects fracture healing due to irisin receptors in human bone tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.