ArticleNature genetics2017
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
Abstract readComparative Study
In one paragraph
Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 9 of them syntheses that pooled it.
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160citing papers in PubMed, 9 pooled it
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
160 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Multi-ancestry genetic architecture of heart failure subtypes.Nature communications · 2026Pooled it
- Exploring associations between estrogen and gene candidates identified by coronary artery disease genome-wide association studies.Frontiers in cardiovascular medicine · 2025Pooled it
- Identifying shared genetic loci and common risk genes of rheumatoid arthritis associated with three autoimmune diseases based on large-scale cross-trait genome-wide association studies.Frontiers in immunology · 2023Pooled it
- Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.Communications biology · 2022Pooled it
- ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.Nature communications · 2019Pooled it
- Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.Nature genetics · 2019Pooled it
- Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.Nature genetics · 2019Pooled it
- Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.Nature communications · 2018Pooled it
- Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Admixture mapping and fine-mapping of birth weight loci in the Black Women's Health Study.Human genetics · 2018Trial
- Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.International journal of molecular sciences · 2018Trial
- New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Dabrafenib and trametinib-induced hyperglycemia with decreased insulin secretion in a patient with lung adenocarcinoma.JCEM case reports · 2026Article
- Blood-based obesity biomarkers and their relevance for disease risk.Nature reviews. Endocrinology · 2026Review
- Comprehensive Analysis of the Roles of the CCDC Protein Family Play in a Range of 58 Disease Processes.Applied biochemistry and biotechnology · 2026Review
- Linking the cardiometabolic index to coronary heart disease in groups with Diabetes and Prediabetes.Scientific reports · 2026Article
- Novel epigenetic marks of insulin resistance trajectories in a longitudinal study of childhood obesity.Cardiovascular diabetology · 2026Article
- Inflammation Mediates the Relationship Between Serum Uric Acid and New-Onset Diabetes Risk in Patients with Coronary Heart Disease: Results from a Multicenter Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Intraflagellar transport-associated CCDC92 is required for spermiogenesis and male fertility in mice.Journal of molecular cell biology · 2025Article
- High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras.Genomics, proteomics & bioinformatics · 2025Review
100 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
94 authors.
Wei ZhaoDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0002-8301-9297
Asif RasheedCenter for Non-Communicable Diseases, Karachi, Pakistan.
Emmi TikkanenDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Jung-Jin LeeTranslational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Joanna M M HowsonMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Rajiv ChowdhuryMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Marju Orho-MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Scott DamrauerDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Aeron SmallDepartment of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Senay AsmaDepartment of Mathematics and Statistics, McMaster University, Hamilton, Ontario, Canada.
Minako ImamuraLaboratory for Endocrinology, Metabolism, and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Toshimasa YamauchDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Peng ChenSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Bishwa R SapkotaDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Nabi ShahCenter for Non-Communicable Diseases, Karachi, Pakistan.
Sehrish JabeenCenter for Non-Communicable Diseases, Karachi, Pakistan.
Praveen SurendranMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Yingchang LuCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Atif ImranCenter for Non-Communicable Diseases, Karachi, Pakistan.
Shahid AbbasFaisalabad Institute of Cardiology, Faisalabad, Pakistan.
Faisal MajeedCenter for Non-Communicable Diseases, Karachi, Pakistan.
Kevin TrindadeTranslational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nadeem QamarNational Institute of Cardiovascular Disorders, Karachi, Pakistan.
Nadeem Hayyat MallickPunjab Institute of Cardiology, Lahore, Pakistan.
Zia YaqoobNational Institute of Cardiovascular Disorders, Karachi, Pakistan.
Tahir SaghirNational Institute of Cardiovascular Disorders, Karachi, Pakistan.
Syed Nadeem Hasan RizviNational Institute of Cardiovascular Disorders, Karachi, Pakistan.
Anis MemonNational Institute of Cardiovascular Disorders, Karachi, Pakistan.
Syed Zahed RasheedKarachi Institute of Heart Diseases, Karachi, Pakistan.
Fazal-Ur-Rehman MemonRed Crescent Institute of Cardiology, Hyderabad, Pakistan.
Khalid MehmoodDepartment of Medicine, Civil Hospital, Karachi, Pakistan.
Naveeduddin AhmedDepartment of Neurology, Liaquat National Hospital, Karachi, Pakistan.
Irshad Hussain QureshiDepartment of Medicine, Mayo Hospital and King Edward Medical University, Lahore, Pakistan.
Tanveer-Us-SalamDepartment of Neurology, Lahore General Hospital, Lahore, Pakistan.
Wasim IqbalDepartment of Neurology, Lahore General Hospital, Lahore, Pakistan.
Uzma MalikDepartment of Medicine, Mayo Hospital and King Edward Medical University, Lahore, Pakistan.
Narinder MehraAll-India Institute of Medical Sciences, New Delhi, India.
Jane Z KuoClinical and Medical Affairs, CardioDx, Inc., Redwood City, California, USA.
Wayne H-H SheuDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Chao A HsiungInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Jyh-Ming J JuangCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Yi-Jen HungDivision of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Thomas QuertermousDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.
I-Te LeeDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Chih-Cheng HsuInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Erwin P BottingerCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sarju RalhanHero DMC Heart Institute Ludhiana, Punjab, India.
Yik Ying TeoSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Tzung-Dau WangCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Dewan S AlamInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Emanuele Di AngelantonioMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Steve EpsteinMedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC, USA.
Sune F NielsenCopenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, Denmark.
Børge G NordestgaardDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Anne Tybjaerg-HansenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Robin YoungMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
CHD Exome+ Consortium
Marianne BennDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Pia R KamstrupDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
EPIC-CVD Consortium
EPIC-Interact Consortium
Michigan Biobank
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Roelof SmitDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Ren-Hua ChungInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Kae-Woei LiangCardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
Sonia AnandDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Dharambir K SangheraDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Samuli RipattiDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jaspal S KoonerDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
E Shyong TaiDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Philippe FrossardCenter for Non-Communicable Diseases, Karachi, Pakistan.
Shiro MaedaLaboratory for Endocrinology, Metabolism, and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Takashi KadowakiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Muredach ReillyCardiology Division, Department of Medicine and the Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA.
Guillaume PareDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.
Daniel J RaderTranslational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
John DaneshMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Benjamin F VoightDepartment of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Danish SaleheenDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0001-6193-020X
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MComprehensive biomarker study to capitalize on existing GWAS in 10K South AsiansRC2HL101834 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DANESH, JOHN NAVID, RADER, DANIEL JAMES · 2009 to 2010
$8.0MAlgorithms to identify non-coding mutational burden and disease-relevant pathwaysR01DK101478 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI VOIGHT, BENJAMIN FRANKLIN · 2014 to 2018
$2.9MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MMarkers of the metabolic syndrome linking type 2 diabetes and MI in South AsiaRC1TW008485 · FIC · UNIVERSITY OF PENNSYLVANIA · PI DANESH, JOHN NAVID, RADER, DANIEL JAMES · 2009 to 2010
$1000kEstablishment of a bioresource for discovery and evaluation of genetic and otherR21NS064908 · NINDS · UNIVERSITY OF CAMBRIDGE · PI DANESH, JOHN NAVID, FROSSARD, PHILIPPE M. · 2009 to 2010
$215kBritish Heart Foundation CH/12/2/29428British Heart Foundation RG/08/014/24067British Heart Foundation RG/13/13/30194British Heart Foundation RG/16/4/32218European Research Council 268834FIC NIH HHS RC1 TW008485Medical Research Council G0800270Medical Research Council MR/L003120/1Medical Research Council MR/P013880/1Medical Research Council MR/P02811X/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NHLBI NIH HHS RC2 HL101834NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK101478NIH HHS S10 OD018522NINDS NIH HHS R21 NS064908Wellcome Trust
Abstract
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D-CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein.
Indexed as
Genome-Wide Association StudyAsiaAsian PeopleBiomarkersComorbidityCoronary DiseaseDiabetes Mellitus, Type 2EuropeGenetic LociGenetic Predisposition to DiseaseHLA-DRB5 ChainsHumansMetabolic Networks and PathwaysMetabolic SyndromeMolecular Targeted TherapyMutation, MissenseBiomarkersHLA-DRB5 Chains
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