ReviewPediatric pulmonology2017
The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review.
Review in Pediatric pulmonology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Global research landscape and emerging trends of respiratory microbiota and asthma: a bibliometric analysis.Frontiers in cellular and infection microbiology · 2026Pooled it
- Early predictors of persistent childhood asthma and allergic rhinitis: A machine learning study using post-hoc explainability.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Upper and lower airway microbiota across infancy and childhood.Pediatric research · 2025Article
- Relationship between prognostic nutritional index and asthma: a cross-sectional analysis.Frontiers in nutrition · 2025Article
- The impact of non-pharmaceutical interventions on community non-SARS-CoV-2 respiratory infections in preschool children.BMC pediatrics · 2024Article
- Early life exposures contributing to accelerated lung function decline in adulthood - a follow-up study of 11,000 adults from the general population.EClinicalMedicine · 2023Article
- Asthma management in low and middle income countries: case for change.The European respiratory journal · 2022Review
- Increased fecal human beta-defensin-2 expression in preterm infants is associated with allergic disease development in early childhood.The World Allergy Organization journal · 2022Article
- Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life-Results from the LoewenKIDS Cohort.Microorganisms · 2022Article
- Birth cohort studies using symptom diaries for assessing respiratory diseases-a scoping review.PloS one · 2022Article
- Bacterial salivary microbiome associates with asthma among african american children and young adults.Pediatric pulmonology · 2019Article
- Factors Beyond Lack of Antibody Govern Pulmonary Complications in Primary Antibody Deficiency.Journal of clinical immunology · 2019Article
- The ABCs of wheeze: Asthma and bacterial communities.PLoS pathogens · 2019Article
- The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review.Pediatric pulmonology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Asthma is a common disease in childhood, and might predispose for chronic obstructive respiratory morbidity in adolescence and adulthood. Various early-life risk factors might influence the risk of wheezing, asthma, and lower lung function in childhood. Cohort studies demonstrated that lower respiratory tract infections in the first years of life are associated with an increased risk of wheezing and asthma, while the association with lung function is less clear. Additionally, the gut and airway microbiome might influence the risk of wheezing and asthma. The interaction between respiratory tract infections and the microbiome complicates studies of their associations with wheezing, asthma, and lung function. Furthermore, the causality behind these observations is still unclear, and several other factors such as genetic susceptibility and the immune system might be of importance. This review is focused on the association of early-life respiratory tract infections and the microbiome with wheezing, asthma, and lung function, it is possible influencing factors and perspectives for future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.