Evidence map›Paper›PMID 28869270›Full record

ArticleMetallomics : integrated biometal science2017

Proteomic and genetic analysis of the response of S. cerevisiae to soluble copper leads to improvement of the antimicrobial function of cellulosic copper nanoparticles.

Xiaoqing Rong-Mullins, Matthew J Winans, Justin B Lee, Zachery R Lonergan, Vincent A Pilolli, Lyndsey M Weatherly, Thomas W Carmenzind, Lihua Jiang, Jonathan R Cumming, Gloria S Oporto and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Metallomics : integrated biometal science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

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  7. Resistance Mechanisms ofG3 (Bethesda, Md.) · 2020
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  14. Transcriptional Profiling ofG3 (Bethesda, Md.) · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaoqing Rong-MullinsDepartment of Biology, West Virginia University, Morgantown, WV, USA. jegallagher@mail.wvu.edu.ORCID 0000-0002-2122-552X
Matthew J WinansDepartment of Biology, West Virginia University, Morgantown, WV, USA. jegallagher@mail.wvu.edu.ORCID 0000-0002-3346-0594
Justin B LeeDepartment of Biology, West Virginia University, Morgantown, WV, USA. jegallagher@mail.wvu.edu.
Zachery R LonerganDepartment of Biology, West Virginia University, Morgantown, WV, USA. jegallagher@mail.wvu.edu.ORCID 0000-0001-7694-2166
Vincent A PilolliDepartment of Biology, West Virginia University, Morgantown, WV, USA. jegallagher@mail.wvu.edu.ORCID 0000-0003-4739-8071
Lyndsey M WeatherlyDepartment of Biology, West Virginia University, Morgantown, WV, USA. jegallagher@mail.wvu.edu.
Thomas W CarmenzindDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Lihua JiangDepartment of Genetics, Stanford University, Stanford University, Stanford, CA, USA.
Jonathan R CummingDepartment of Biology, West Virginia University, Morgantown, WV, USA. jegallagher@mail.wvu.edu.ORCID 0000-0002-4855-7460
Gloria S OportoDivision of Forestry and Natural Resources, West Virginia University, Morgantown, WV, USA.ORCID 0000-0001-7115-1154
Jennifer E G GallagherDepartment of Biology, West Virginia University, Morgantown, WV, USA. jegallagher@mail.wvu.edu.ORCID 0000-0002-6163-3181
West Virginia University · USStanford Medicine · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
BECTON-DICKINSON FACSARIA FLOW CYTOMETER: SARCOPENIAS10RR020866 · NCRR · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2006 to 2006
$425k
Special Becton Dickinson Fortessa Flow CytometerS10OD016165 · OD · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2013 to 2013
$384k
NCRR NIH HHS S10 RR020866NIH HHS S10 OD016165
6 · The paper itself

Abstract

Copper (Cu) was used in antiquity to prevent waterborne and food diseases because, as a broad-spectrum antimicrobial agent, it generates reactive oxygen species, ROS. New technologies incorporating Cu into low-cost biodegradable nanomaterials built on cellulose, known as cellulosic cupric nanoparticles or c-CuNPs, present novel approaches to deliver Cu in a controlled manner to control microbial growth. We challenged strains of Saccharomyces cerevisiae with soluble Cu and c-CuNPs to evaluate the potential of c-CuNPs as antifungal agents. Cells exposed to c-CuNPs demonstrated greater sensitivity to Cu than cells exposed to soluble Cu, although Cu-resistant strains were more tolerant than Cu-sensitive strains of c-CuNP exposure. At the same level of growth inhibition, 157 μM c-CuNPs led to the same internal Cu levels as did 400 μM CuSO

Indexed as

Antifungal AgentsCation Transport ProteinsCelluloseCopperGene Expression Regulation, FungalMetallothioneinMetal NanoparticlesMicrobial Sensitivity TestsProteomeProteomicsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAntifungal AgentsCation Transport ProteinsCelluloseCopperCUP1-1 protein, S cerevisiaeMetallothioneinProteomeSaccharomyces cerevisiae ProteinsZRT2 protein, S cerevisiae

Identifiers

PMID28869270
PMCPMC5741080
OpenAlexW2750127947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.