Evidence map›Paper›PMID 28869095›Full record

ReviewTrends in cardiovascular medicine2018

Biology and clinical relevance of noncoding sno/scaRNAs.

Thuy Cao, Sheeja Rajasingh, Saheli Samanta, Buddhadeb Dawn, Douglas C Bittel, Johnson Rajasingh

Abstract readReview
In one paragraph

Review in Trends in cardiovascular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. What is the Role of SNORA42 in Carcinogenesis? A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2023
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Thuy CaoDivision of Cardiovascular Diseases, Department of Internal Medicine, Cardiovascular Research Institute, Kansas City, KS.
Sheeja RajasinghDivision of Cardiovascular Diseases, Department of Internal Medicine, Cardiovascular Research Institute, Kansas City, KS.
Saheli SamantaDivision of Cardiovascular Diseases, Department of Internal Medicine, Cardiovascular Research Institute, Kansas City, KS.
Buddhadeb DawnDivision of Cardiovascular Diseases, Department of Internal Medicine, Cardiovascular Research Institute, Kansas City, KS.
Douglas C BittelChildren Mercy Hospital, Kansas City, MO.
Johnson RajasinghDivision of Cardiovascular Diseases, Department of Internal Medicine, Cardiovascular Research Institute, Kansas City, KS; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS. Electronic address: rjohnson9@kumc.edu.
Mercy Medical Center · USUniversity of Kansas Medical Center · US

Funding

Transgenic and Gener-Targeting CoreP20GM104936 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN · 2012 to 2016
$10.9M
Epigenetic modification of endothelial progenitor cells into multipotent cellsR21HL097349 · NHLBI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JOHNSON, RAJASINGH · 2009 to 2010
$432k
NHLBI NIH HHS R21 HL097349NIGMS NIH HHS P20 GM104936
6 · The paper itself

Abstract

Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that perform various biological functions, including biochemical modifications of other RNAs, precursors of miRNA, splicing, and telomerase activity. The small Cajal body-associated RNAs (scaRNAs) are a subset of the snoRNA family and collect in the Cajal body where they perform their canonical function to biochemically modify spliceosomal RNAs prior to maturation. Failure of sno/scaRNAs have been implicated in pathology such as congenital heart anomalies, neuromuscular disorders, and various malignancies. Thus, understanding of sno/scaRNAs demonstrates the clinical value.

Indexed as

Active Transport, Cell NucleusAnimalsCoiled BodiesGene Expression RegulationGenetic Predisposition to DiseaseHumansMicroRNAsRNA, MessengerRNA Processing, Post-TranscriptionalRNA, RibosomalRNA, Small NucleolarRNA SplicingRNA, TransferTelomeraseMicroRNAsRNA, MessengerRNA, RibosomalRNA, Small NucleolarRNA, TransferTelomeraseAlternative splicingNoncoding RNASmall Cajal body-associated RNASmall nucleolar RNASpliceosomal RNA

Identifiers

PMID28869095
PMCPMC5762389
OpenAlexW2745046296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.