ArticleActa orthopaedica et traumatologica turcica2017
Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations.
Article in Acta orthopaedica et traumatologica turcica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Necrosis following neoadjuvant radiotherapy and its association with oncological outcome in soft tissue sarcoma patients: a systematic literature review and meta-analysis.EFORT open reviews · 2026Pooled it
- Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: A Nonrandomized Controlled Trial.JAMA oncology · 2021Trial
- Limb Salvage in Myxoid Liposarcoma With Tumor Prosthetic Reconstruction: A Case Report and Literature Review.Cureus · 2026Article
- Review
- Myxoid liposarcoma: treatment outcomes, metastatic pattern and volumetric analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- Evaluation of Prognostic Factors in Myxoid Liposarcoma Treated with Combined Neoadjuvant Radiotherapy and Surgical Excision: Systematic Review.Diseases (Basel, Switzerland) · 2025Review
- Heterogeneity in response to neoadjuvant radiotherapy between soft tissue sarcoma histotypes: associations between radiology and pathology findings.European radiology · 2025Article
- Significance of radiation therapy in the myxoid round-cell liposarcoma treatment regimen.International journal of clinical oncology · 2024Article
- Enormous myxoid/round cell liposarcoma: A case report.Rare tumors · 2024Article
- Histological response to radiotherapy is an early event in myxoid liposarcoma.Virchows Archiv : an international journal of pathology · 2023Article
- Prognosis of Liposarcoma Patients in Modern ERA: Single-Center Experience.South Asian journal of cancer · 2022Article
- Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic Pattern.Cancers · 2022Article
- Artificial intelligence significantly improves the diagnostic accuracy of deep myxoid soft tissue lesions in histology.Scientific reports · 2022Article
- Evaluation of prognostic factors and oncological outcomes in patients with limb-localized myxoid liposarcoma.Joint diseases and related surgery · 2022Article
- Preoperative Radiation for Soft Tissue Sarcomas: How Much Is Needed?Current treatment options in oncology · 2022Review
- Magnetic resonance imaging of trunk and extremity myxoid liposarcoma: diagnosis, staging, and response to treatment.Skeletal radiology · 2021Review
- Management of myxoid liposarcoma of the extremity.Oncology letters · 2021Review
- Magnetic resonance imaging assessment of chemotherapy-related adipocytic maturation in myxoid/round cell liposarcomas: specificity and prognostic value.The British journal of radiology · 2020Article
- Prognostic factors of patients with extremity myxoid liposarcomas after surgery.Journal of orthopaedic surgery and research · 2019Article
- Prognostic Significance of Histological Subtype in Soft Tissue Sarcoma With Distant Metastasis.In vivo (Athens, Greece)Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate the histopathological features of primary extremity myxoid liposarcoma before and after neoadjuvant radiation therapy, and to evaluate the oncological outcomes of the patients.
methodsThe study included 23 patients (16 men and 7 women with a mean age of 43 (24-69) years) with primary myxoid liposarcoma of the extremities, who were treated between January 1998 and December 2015. Inclusion criteria were histopathological confirmation of the diagnosis with both the initial biopsy and the resection specimen, and having undergone neoadjuvant radiotherapy. Demographic, clinical and histopathological data were evaluated.
resultsOver a mean follow-up time of 55.2 (8-139) months, 5 patients (21.7%) died secondary to disease progression, leaving 18 patients (78.3%) still alive at the time of last follow-up. Only one patient (4%) experienced local recurrence and six (26%) patients developed distant metastases. Disease-free survival at 5 and 10 years were 66%; whereas, overall patient survival at 5 and 10 years were 78.1% and 71.0%, respectively. Tumor size (>15 cm) and presence of metastasis were significantly associated with increased overall mortality. On histopathology, necrosis was present in 12/23 resection specimens. Hyalinization/fibrosis and residual viable tumor was present in all specimens. Adipocytic maturation/cytodifferentiation was seen in 8/23 patients.
conclusionNeoadjuvant radiotherapy was effective for myxoid liposarcomas histopathologically, although these histopathological features did not affect the patients' oncological outcomes. Favorable oncological outcomes were obtained with neoadjuvant radiotherapy, surgical resection and chemotherapy. LEVEL OF EVIDENCE: Level IV, therapeutic study.
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