Evidence map›Paper›PMID 28868970›Full record

ReviewNanomedicine (London, England)2017

The use of nanoparticulates to treat breast cancer.

Xiaomeng Tang, Welley S Loc, Cheng Dong, Gail L Matters, Peter J Butler, Mark Kester, Craig Meyers, Yixing Jiang, James H Adair

Open access · greenAbstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 125 citations in OpenAlex.

  1. Amine-Functionalized and Gold-Decorated Amine-Functionalized TiOInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
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  7. Bioactivity of mycosynthesized nanoparticles assists photothermal therapy of breast cancer cells.Apoptosis : an international journal on programmed cell death · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Antioxidant Enzymes and Their Potential Use in Breast Cancer Treatment.International journal of molecular sciences · 2024
    Review
  18. A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era.International journal of molecular sciences · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xiaomeng TangDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.
Welley S LocDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.
Cheng DongDepartment of Bioengineering, Pennsylvania State University, University Park, PA 16802, USA.
Gail L MattersDepartment of Biochemistry & Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Peter J ButlerDepartment of Bioengineering, Pennsylvania State University, University Park, PA 16802, USA.
Mark KesterDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Craig MeyersDepartment of Microbiology & Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Yixing JiangMarlene & Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
James H AdairDepartment of Materials Science & Engineering, Pennsylvania State University, University Park, PA 16802, USA.
Pennsylvania State University · USUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer CenterUniversity of Virginia · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
NRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4M
Novel Nanoparticle Therapy for Pancreatic CancerR01CA167535 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KESTER, MARK, MATTERS, GAIL L. · 2013 to 2017
$1.6M
Targeting Pancreatic Cancer with Aptamers to the CCK-B ReceptorR21CA170121 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MATTERS, GAIL L. · 2013 to 2014
$361k
NCATS NIH HHS TL1 TR002016NCATS NIH HHS UL1 TR002014NCI NIH HHS R01 CA167535NCI NIH HHS R21 CA170121
6 · The paper itself

Abstract

Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors. Currently available and clinically applicable innovative nanoparticulate-based systems for breast cancer nanotherapies are discussed in this review.

Indexed as

AnimalsBiological TransportBreast NeoplasmsDrug Delivery SystemsDrug LiberationFemaleHumansNanomedicineNanoparticlesParticle SizePermeabilitySurface Propertiesbreast cancergene/drug deliverynanoparticles

Identifiers

PMID28868970
PMCPMC5612024
OpenAlexW2752197859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.