Evidence map›Paper›PMID 28868906›Full record

ReviewEuropean heart journal. Acute cardiovascular care2019

Therapeutic application of contrast ultrasound in ST elevation myocardial infarction: Role in coronary thrombosis and microvascular obstruction.

Jeroen Slikkerveer, Lynda Jm Juffermans, Niels van Royen, Yolande Appelman, Thomas R Porter, Otto Kamp

Open access · hybridAbstract readReview
In one paragraph

Review in European heart journal. Acute cardiovascular care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Feasibility of sonothrombolysis in the ambulance for ST-elevation myocardial infarction.The international journal of cardiovascular imaging · 2022
    Article
  6. Sonothrombolysis in the ambulance for ST-elevation myocardial infarction: rationale and protocol.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Targeted, Site-Specific, Delivery Vehicles of Therapeutics for COVID-19 Patients. Brief Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jeroen Slikkerveer1 Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands.
Lynda Jm Juffermans1 Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands.
Niels van Royen1 Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands.
Yolande Appelman1 Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands.
Thomas R Porter4 University of Nebraska Medical Center, Omaha, Nebraska, USA.
Otto Kamp1 Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLUniversity of Nebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past few decades, cardiac ultrasound has become a widely available, easy-to-use diagnostic tool in many scenarios in acute cardiac care. The introduction of microbubbles extended its diagnostic value. Not long thereafter, several investigators explored the therapeutic potential of contrast ultrasound on thrombus dissolution. Despite large improvements in therapeutic options, acute ST elevation myocardial infarction remains one of the main causes of mortality and morbidity in the western world. The therapeutic effect of contrast ultrasound on thrombus dissolution might prove to be a new, effective treatment strategy in this group of patients. With the recent publication of human studies scrutinising the therapeutic options of ultrasound and microbubbles in ST elevation myocardial infarction, we have entered a new stage in this area of research. This therapeutic effect is based on biochemical effects both at macrovascular and microvascular levels, of which the exact working mechanisms remain to be elucidated in full. This review will give an up-to-date summary of our current knowledge of the therapeutic effects of contrast ultrasound and its potential application in the field of ST elevation myocardial infarction, along with its future developments.

Indexed as

Contrast MediaCoronary AngiographyCoronary CirculationCoronary ThrombosisEchocardiographyHumansMicrocirculationST Elevation Myocardial InfarctionUltrasonography, InterventionalContrast Mediacoronary thrombosisechocardiographymicrobubblesmicrovascular obstructionST elevation myocardial infarction

Identifiers

PMID28868906
PMCPMC6376593
OpenAlexW2752534602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.