Evidence map›Paper›PMID 28868615›Full record

ReviewAnnals of the New York Academy of Sciences2018

Mechanisms of weight loss and improved metabolism following bariatric surgery.

Christopher M Mulla, Roeland J W Middelbeek, Mary-Elizabeth Patti

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 92 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 4 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03385707 active not recruitingnot on this mapstarted 2019, after this paper: background citation

Hypoglycemia and the Gut Microbiome

TypeobservationalSponsorJoslin Diabetes CenterRan2019 to 2026Enrolled28ConditionsHypoglycemia
NCT04132531 completednot on this map

Impact of Bariatric Surgery on Circulating Inflammatory and Pro-vascular Progenitor Cell Populations.

TypeobservationalSponsorUnity Health TorontoRan2018 to 2019Enrolled38ConditionsObesity, Morbid, Stem Cells, Cardiovascular MorbidityArmsBariatric (weight loss) surgery
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 4 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
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  14. Towards a better mouse model of vertical sleeve gastrectomy.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025
    Article
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christopher M MullaResearch and Clinic Divisions, Joslin Diabetes Center, Boston, Massachusetts.
Roeland J W MiddelbeekResearch and Clinic Divisions, Joslin Diabetes Center, Boston, Massachusetts.
Mary-Elizabeth PattiResearch and Clinic Divisions, Joslin Diabetes Center, Boston, Massachusetts.
Joslin Diabetes Center · USHarvard University · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
TRAINING IN DIABETES AND METABOLISMT32DK007260 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 1986 to 2026
$13.6M
Paternal Contributions to Metabolic Disease in Offspring: Environment, Epigenetics, and SpermR01DK106193 · NIDDK · JOSLIN DIABETES CENTER · PI PATTI, MARY E · 2016 to 2024
$4.3M
Closed-Loop Glucagon Pump for Treatment of Post-Bariatric HypoglycemiaR44DK107114 · NIDDK · XERIS PHARMACEUTICALS, INC. · PI DASSAU, EYAL, PATTI, MARY E · 2015 to 2017
$1.8M
Exercise Regulation of Human Adipose TissueR01DK112283 · NIDDK · JOSLIN DIABETES CENTER · PI GOODYEAR, LAURIE J · 2016 to 2018
$1.2M
ARMMS-T2DU34DK107917 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI KIRWAN, JOHN P., SCHAUER, PHILIP RAYMOND · 2015 to 2016
$731k
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK106193NIDDK NIH HHS R01 DK112283NIDDK NIH HHS R44 DK107114NIDDK NIH HHS T32 DK007260NIDDK NIH HHS U34 DK107917
6 · The paper itself

Abstract

Bariatric surgery is increasingly recognized as one of the most effective interventions to help patients achieve significant and sustained weight loss, as well as improved metabolic and overall health. Unfortunately, the cellular and physiological mechanisms by which bariatric surgery achieves weight loss have not been fully elucidated, yet are critical to understanding the central role of the intestinal tract in whole-body metabolism and to developing novel strategies for the treatment of obesity. In this review, we provide an overview of potential mechanisms contributing to weight loss, including effects on regulation of energy balance and both central and peripheral nervous system regulation of appetite and metabolism. Moreover, we highlight the importance of the gastrointestinal tract, including alterations in bile acid physiology, secretion of intestinally derived hormones, and the microbiome, as a potent mediator of improved metabolism in postbariatric patients.

Indexed as

Bariatric SurgeryEnergy MetabolismAppetiteBile Acids and SaltsClinical Trials as TopicEnergy IntakeFeeding BehaviorGastrointestinal HormonesGastrointestinal MicrobiomeHumansIntestinesNutrientsObesityPrevalenceRewardVagus NerveBile Acids and SaltsGastrointestinal HormonesNutrientsadjustable gastric bandbariatric surgeryobesityRoux-en-Y gastric bypasssleeve gastrectomy

Identifiers

PMID28868615
PMCPMC5788713
OpenAlexW2751603645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.