Evidence map›Paper›PMID 28868588›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Maternal vitamin D and offspring trabecular bone score.

N K Hyde, S L Brennan-Olsen, J D Wark, S M Hosking, K L Holloway, J A Pasco

Abstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Early Life Programming of Skeletal Health.Current osteoporosis reports · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

N K HydeEpi-Centre for Healthy Ageing, IMPACT SRC, School of Medicine, Deakin University (Barwon Health), PO Box 281, Geelong, VIC, 3220, Australia. nhyde@barwonhealth.org.au.
S L Brennan-OlsenEpi-Centre for Healthy Ageing, IMPACT SRC, School of Medicine, Deakin University (Barwon Health), PO Box 281, Geelong, VIC, 3220, Australia.
J D WarkDepartment of Medicine, Bone and Mineral Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.
S M HoskingEpi-Centre for Healthy Ageing, IMPACT SRC, School of Medicine, Deakin University (Barwon Health), PO Box 281, Geelong, VIC, 3220, Australia.
K L HollowayEpi-Centre for Healthy Ageing, IMPACT SRC, School of Medicine, Deakin University (Barwon Health), PO Box 281, Geelong, VIC, 3220, Australia.
J A PascoEpi-Centre for Healthy Ageing, IMPACT SRC, School of Medicine, Deakin University (Barwon Health), PO Box 281, Geelong, VIC, 3220, Australia.
Deakin University · AUAustralian Institute for Musculoskeletal Science · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

No studies have explored the relationship with maternal vitamin D (25(OH)D) in pregnancy and offspring trabecular bone score (TBS). Our data suggest that maternal 25(OH)D in early pregnancy, but not late, may be associated with offspring TBS in boys. These data act as hypothesis-generating findings for confirmation in larger, longer-term studies.

introductionTrabecular bone score (TBS), a novel tool derived from dual-energy X-ray absorptiometry (DXA), reflects the microarchitecture of the vertebrae. It has been shown to predict fracture independent of standard DXA parameters in adult populations. Previously, we demonstrated that maternal serum 25-hydroxyvitamin D (25(OH)D) during pregnancy is associated with offspring bone mineral content at age 11 years. However, associations with TBS have not been explored, thus we aimed to determine associations between maternal 25(OH)D and offspring TBS.

methodsData were collected from the Vitamin D in Pregnancy (VIP) study. Venous blood samples were taken at recruitment and at 28-32 weeks' gestation. Maternal 25(OH)D was measured by radioimmunoassay. Offspring (n = 195, n = 181 with complete measures) underwent spine DXA (GE Lunar), at age 11 years (median = 10.9 (IQR 10.9-11.4)). TBS was calculated using TBS iNsight software.

resultsOffspring of mothers with sufficient 25(OH)D levels (≥50 nmol/L) at recruitment had a higher TBS (1.363 vs. 1.340, p = 0.04). In multivariable linear regression models, after adjustment for child relative lean mass, sex and pubertal stage, a 10 nmol/L increase in maternal 25(OH)D was associated with a 0.005 (95% CI 0.000, 0.010, p = 0.04) increase in TBS. However when stratified by sex (p for interaction = 0.16), the association was significant in boys, but not girls. There were no associations with TBS and maternal 25(OH)D at 28-32 weeks.

conclusionsWe speculate that maternal 25(OH)D in early pregnancy may be associated with TBS in offspring at age 11 in boys. These hypothesis-generating findings warrant confirmation with larger interventional and long-term follow-up studies.

Indexed as

Absorptiometry, PhotonAdultAnthropometryBone DevelopmentCancellous BoneChildFemaleFollow-Up StudiesHumansMalePregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsPrenatal Nutritional Physiological PhenomenaVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin DMaternalOffspringPregnancyTrabecular bone scoreVitamin D

Identifiers

PMID28868588
OpenAlexW2751170511

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.