Evidence map›Paper›PMID 28868583›Full record

ArticleImmunologic research2017

Von Willebrand factor protects against acute CCl

Hai-Jian Sun, Jian Chen, Hao Zhang, Bing Ni, Jennifer C van Velkinburgh, Yao Liu, Yu-Zhang Wu, Xia Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Fibrinogen superfamily proteins: Key regulators in hepatic disorders.World journal of experimental medicine · 2025
    Review
  3. Article
  4. Review
  5. Pharmacokinetics and Therapeutic Potential ofLife (Basel, Switzerland) · 2022
    Article
  6. Article
  7. Article
  8. Frontiers in microbiology · 2022
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hai-Jian SunInstitute of Immunology, Third Military Medical University (Military Medical University of the Army), PLA, Chongqing, 400038, People's Republic of China.
Jian ChenInstitute of Immunology, Third Military Medical University (Military Medical University of the Army), PLA, Chongqing, 400038, People's Republic of China.
Hao ZhangInstitute of Immunology, Third Military Medical University (Military Medical University of the Army), PLA, Chongqing, 400038, People's Republic of China.
Bing NiDepartment of Pathophysiology and High Altitude Pathology, Third Military Medical University (Military Medical University of the Army), Chongqing, 400038, People's Republic of China.
Jennifer C van Velkinburghvan Velkinburgh Initiative for Collaboratory BioMedical Research, Santa Fe, NM, 87501, USA.
Yao LiuDepartment of Pharmacy, Southwestern Hospital, Chongqing, 400038, People's Republic of China.
Yu-Zhang WuInstitute of Immunology, Third Military Medical University (Military Medical University of the Army), PLA, Chongqing, 400038, People's Republic of China. wuyuzhang20006@sohu.com.
Xia YangInstitute of Immunology, Third Military Medical University (Military Medical University of the Army), PLA, Chongqing, 400038, People's Republic of China. oceanyx@126.com.
Army Medical University · CNSouthwest Hospital · CN

Funding

National key research and development program YS2016YFJC040220National Natural Science Foundation of China No. 31500710
6 · The paper itself

Abstract

The blood glycoprotein von Willebrand factor (vWF) is involved in coagulopathy and inflammation; however, its role in the pathogenesis of acute liver failure, as suggested by its higher expression levels in such patients, remains unknown. In this study, vWF-knockout (KO) mice showed more severe carbon tetrachloride (CCl

Indexed as

AnimalsCarbon TetrachlorideChemical and Drug Induced Liver InjuryEndothelium, VascularExtracellular Signal-Regulated MAP KinasesFibrinogenHumansHuman Umbilical Vein Endothelial CellsMiceMice, Inbred C57BLMice, KnockoutMicroarray AnalysisSignal TransductionTranscriptomevon Willebrand FactorCarbon TetrachlorideExtracellular Signal-Regulated MAP KinasesFgl2 protein, mouseFibrinogenvon Willebrand FactorAcute liver injuryCarbon tetrachlorideFibrinogen-like protein 2von Willebrand Factor

Identifiers

PMID28868583
OpenAlexW2752423828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.