ArticleGE Portuguese journal of gastroenterology
Association Between IL-4 and IL-6 Expression Variants and Gastric Cancer Among Portuguese Population.
Article in GE Portuguese journal of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Statistical meta-analysis to investigate the association between the Interleukin-6 (IL-6) gene polymorphisms and cancer risk.PloS one · 2021Pooled it
- Association of cytokine gene polymorphisms with peripheral neuropathy susceptibility in people living with HIV in Greece.Journal of neurovirology · 2023Article
- The Effect of IL-6 174G > C Gene Polymorphism on Gastrointestinal Cancer: a Systematic Review and Meta-analysis.Indian journal of surgical oncology · 2023Review
- Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.International journal of molecular sciences · 2021Review
- Review
- Association of angiogenesis and inflammation-related gene functional polymorphisms with early-stage breast cancer prognosis.Oncology letters · 2020Article
- Review
- IL-6 and miR-1271 expression levels in elderly and young gastric cancer patients and correlation analysis with prognosis.Oncology letters · 2019Article
- Interleukin-6 Genetic Variation and Susceptibility to Gastric Cancer in an Iranian PopulationAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Genetic Variations and Gastric Cancer Risk.GE Portuguese journal of gastroenterologyArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMultiple studies have reported strong associations between
aimThis study aimed to investigate the impact of common IL-4 and IL-6 polymorphisms in GC development risk among Portuguese population.
methodsA total of 100 GC biopsies (50 with intestinal type, IGC, 50 with diffuse type, DGC) and 50 chronic gastritis cases, used as control group, were included in this case-control study. IL-4 and IL-6 common polymorphisms were genotyped by PCR-SSP, using commercially available kits.
resultsIL-4 low producer genotypes, IL-4-590TT (OR = 6.7; 95% CI 1.4-32.4) and IL-4-1098GG (OR = 4.4; 95% CI 1.7-16.9) were found associated with IGC and DGC, respectively. We also verified that IL-4 TTT haplotype was linked with both IGC (OR = 5.8; 95% CI 2.3-14.4) and DGC (OR = 2.3; 95% CI 1.0-5.5) groups. Concerning IL-6 results, IL-6-174CG genotype showed a higher prevalence among IGC cases (OR = 7.3; 95% CI 2.7-20.3), and IL-6-174CC (OR = 3.8; 95% CI 1.7-8.7) showed upper prevalence within DGC subjects. Finally, IL-6-174/nt565CG haplotype showed a significant association with both IGC (OR = 7.3; 95% CI 2.7-20.3) and DGC (OR = 7.9; 95% CI 4.2-14.9).
conclusionIL-6 and IL-4 expression variants seem to have an important role in GC risk mechanisms. This study provides preliminary evidence that IL-4 and IL-6 polymorphisms, although not directly linked to the disease, may be useful tools in the study of this multifactorial disease.
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