Evidence map›Paper›PMID 28868323›Full record

ArticleJournal of alcoholism and drug dependence2017

Fetal Alcohol Exposure: The Common Toll.

Marie R Nakhoul, Karl E Seif, Natasha Haddad, Georges E Haddad

Open access · greenAbstract read
In one paragraph

Article in Journal of alcoholism and drug dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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  8. The effects ofJournal of developmental origins of health and disease · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marie R NakhoulDepartment of Physiology and Biophysics, College of Medicine, Howard University, Washington, D.C, USA.
Karl E SeifDepartment of Physiology and Biophysics, College of Medicine, Howard University, Washington, D.C, USA.
Natasha HaddadDepartment of Physiology and Biophysics, College of Medicine, Howard University, Washington, D.C, USA.
Georges E HaddadDepartment of Physiology and Biophysics, College of Medicine, Howard University, Washington, D.C, USA.
Howard University · US

Funding

STRUCTURAL/FUNCTIONAL CHARACTERIZATION OF AMINOGLYCOSIDEG12RR003048 · NCRR · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 1985 to 2011
$19.0M
MECHANISMS OF ALCOHOL-INDUCED CARDIOMYOPATHY.R15AA019816 · NIAAA · HOWARD UNIVERSITY · PI HADDAD, GEORGES E. · 2011 to 2011
$442k
NCRR NIH HHS G12 RR003048NIAAA NIH HHS R15 AA019816
6 · The paper itself

Abstract

Alcohol has always been present in human life, and currently it is estimated that 50% of women of childbearing age consume alcohol. It has become increasingly clear over the last years that alcohol exposure during fetal development can have detrimental effects on various organ systems, and these effects are exerted by alcohol through multiple means, including effects on free radical formation, cellular apoptosis, as well as gene expression. Fetal alcohol exposure can lead to a spectrum of short term as well as long-term problems, with Fetal Alcohol Syndrome being on the more severe end of that spectrum. This syndrome is morbid, yet preventable, and is characterized by midfacial hypoplasia, thin upper lip, widely spaced small eyes, long smooth philtrum and inner epicanthal folds. Other findings include growth restriction as well as various neurodevelopmental abnormalities. This article is the first comprehensive review combining the molecular as well as the gross physiological and anatomical effects of alcohol exposure during pregnancy on various organ systems in the body. Our knowledge of these various mechanisms is crucial for our understanding of how alcohol exposure during fetal development can lead to its detrimental effects.

Indexed as

Alcohol and brainAlcohol and heartApoptosisCardiac defectDevelopmentFetal alcohol exposurePregnancyReactive oxygen species

Identifiers

PMID28868323
PMCPMC5575798
OpenAlexW2592317956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.