ArticleAorta (Stamford, Conn.)2017
Cause of Death Following Surgery for Acute Type A Dissection: Evidence from the Canadian Thoracic Aortic Collaborative.
Article in Aorta (Stamford, Conn.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The Association Between Glucagon-like Peptide-1 Receptor Agonists and Clinical Outcomes in Patients with Thoracic Aortic Aneurysm.Diagnostics (Basel, Switzerland) · 2026Article
- Association of 3-Day Postoperative Blood Glucose Variability With All-Cause Mortality in ICU Patients After Surgical Repair of Acute Type A Aortic Dissection: A Retrospective Cohort Study Using the MIMIC-IV Database.Clinical cardiology · 2026Article
- Brachial artery cannulation for right upper limb ischemia secondary to acute type A aortic dissection.Journal of surgical case reports · 2026Article
- A Novel Aortic End-to-End Anastomotic Stapler Device-Results of a Human Cadaver Study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026Article
- A Comprehensive Review of Acute Type A Aortic Dissection: Epidemiology, Classification, Management Strategies, Mortality Risk Assessment, and Ethical Considerations for Patients who Refuse Blood Transfusions.Reviews in cardiovascular medicine · 2025Review
- Article
- Predicting Thoracic Aortic Dissection in a Diverse Biobank Using a Polygenic Risk Score.JACC. Advances · 2025Article
- Clinical implication of NT-proBNP to predict mortality in patients with acute type A aortic dissection: a retrospective cohort study.BMJ open · 2025Article
- Diabetes does not increase in-hospital or short-term mortality in patients undergoing surgical repair for type A aortic dissection: insight from the national readmission database.Cardiovascular diabetology · 2024Article
- Successful Percutaneous Treatment of Left Main Artery Occlusion Associated With Focal Type A Aortic Dissection.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Endovascular Repair of Zone 0 Ascending Aortic Aneurysm: A Review of Current Knowledge and Developing Technology.Aorta (Stamford, Conn.) · 2024Article
- Temperature management in acute type A aortic dissection treatment: deep vs. moderate hypothermic circulatory arrest. Is colder better?Frontiers in cardiovascular medicine · 2024Article
- The role of surgeon's intuition for acute type A aortic dissection in an era of evidence-based medicine: a prospective cohort study.Journal of thoracic disease · 2023Article
- Postoperative glucocorticoids in patients with acute type A aortic dissection (GLAD): study protocol for a prospective, single-center, randomized controlled trial.BMC anesthesiology · 2023Article
- Extensive aortic dissection (Stanford Type A) presenting with confusion in a patient: a case report.Radiology case reports · 2022Article
- Optimal Extent of Repair for Acute Type I Aortic Dissection-Frozen Elephant Trunk? How Long and Why?Aorta (Stamford, Conn.) · 2022Article
- Prior intake of new oral anticoagulants adversely affects outcome following surgery for acute type A aortic dissection.Interactive cardiovascular and thoracic surgery · 2022Article
- Acute type A aortic dissection and the consequences of a patent false lumen.JTCVS techniques · 2021Article
- Preoperative Imaging Risk Findings for Postoperative New Stroke in Patients With Acute Type A Aortic Dissection.Frontiers in cardiovascular medicine · 2020Article
- Impact of ascending aortic, hemiarch and arch repair on early and long-term outcomes in patients with Stanford A acute aortic dissection.Therapeutic advances in cardiovascular disease · 2018Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgery confers the best chance of survival following acute Type A dissection (ATAD), yet perioperative mortality remains high. Although perioperative risk factors for mortality have been described, information on the actual causes of death is sparse. In this study, we aimed to characterize the inciting events causing death during surgical repair of ATAD.
methodsNine centers participated in the study. We included all patients who died following surgical repair for ATAD between January 2007 and December 2013. An aortic surgeon at each site determined the primary cause of death from seven predetermined categories: cardiac, stroke, hemorrhage, other organ ischemia (peripheral, renal, or visceral), multiorgan failure, sepsis, or other causes. Additional characteristics and variables were analyzed to delineate potential modifiable factors for mortality.
resultsOf the 692 surgeries for ATAD, there were 123 deaths (17.8% mortality rate). Mean age at death was 66 years. Events contributing to death were: cardiac (25%), stroke (22%), hemorrhage (21%), multiorgan failure (12%), other organ ischemia (11%), sepsis (4%), and other causes (5%). Neurologic injury at presentation was a predictor of stroke as the inciting cause of death (p = 0.04). Peripheral, renal, or visceral ischemia at presentation was highly predictive of death due to these presenting ischemic conditions (p = 0.004). We found no associations between cardiogenic shock, tamponade, or cardiopulmonary bypass duration and cardiac death.
conclusionOperative mortality for ATAD remains high in Canada. Nearly 70% of deaths arise from cardiac failure, stroke, or hemorrhage. Therefore, novel surgical, hybrid, and endovascular strategies should target these three areas.
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