ArticleEuropean thyroid journal2017
TPOAb and Thyroid Function Are Not Associated with Breast Cancer Outcome: Evidence from a Large-Scale Study Using Data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001).
Article in European thyroid journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influence of the anti-oestrogens tamoxifen and letrozole on thyroid function in women with early and advanced breast cancer: A systematic review.Cancer medicine · 2023Pooled it
- Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?Future science OA · 2021Trial
- Association between benign thyroid disease and breast cancer: a single center experience.BMC endocrine disorders · 2019Trial
- Anti-TPO antibody and thyroid hormone levels in Iranian female breast cancer patients and their association with prognostic factors: a case-control study.European journal of translational myology · 2023Article
- Cancer-specific mortality in breast cancer patients with hypothyroidism: a UK population-based study.Breast cancer research and treatment · 2022Article
- Case report: Lymph node metastases of breast cancer and thyroid cancer encountered in axilla.Frontiers in oncology · 2022Article
- µ-Crystallin Is Associated with Disease Outcome in Head and Neck Squamous Cell Carcinoma.Journal of personalized medicine · 2021Article
- Co-occurrence of thyroid and breast cancer is associated with an increased oncogenic SNP burden.BMC cancer · 2021Article
- Thyroid peroxidase in human endometrium and placenta: a potential target for anti-TPO antibodies.Clinical and experimental medicine · 2021Article
- Incidence of hypothyroidism after treatment for breast cancer-a Danish matched cohort study.Breast cancer research : BCR · 2020Article
- Breast cancer prognosis is better in patients who develop subsequent metachronous thyroid cancer.PloS one · 2019Article
- Biochemical properties of thyroid peroxidase (TPO) expressed in human breast and mammary-derived cell lines.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSmall-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome.
objectivesWe aimed to clarify this association in a large cohort using the phase III, randomized, controlled Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001).
methodsTACT women >18 years old with node-positive or high-risk node-negative early breast cancer (pT1-3a, pN0-1, M0), with stored plasma (
resultsNo difference in DFS was found by TPOAb status (unadjusted hazard ratio [HR]: 0.97, 95%CI: 0.78-1.19;
conclusionsNo evidence for a prognostic role of TPOAb and/or thyroid function in moderate-to-high-risk early breast cancer was found in the largest and longest observational study to date.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.