Evidence map›Paper›PMID 28868218›Full record

Article3 Biotech2017

Optimization of the secretory expression of recombinant human C-reactive protein in

Junming Li, Chengming Sun, Lei Chen, Lihui Sun, Lijun Duan, Qing Zheng, Xuejun Hu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in 3 Biotech, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. High-level expression of3 Biotech · 2019
    Article
  4. High-level expression of3 Biotech · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Junming Li *Department of Clinical Laboratory, Yuhuangding Hospital, Yantai, 264000 Shandong China.
Chengming Sun *Department of Clinical Laboratory, Yuhuangding Hospital, Yantai, 264000 Shandong China.
Lei ChenDepartment of Clinical Laboratory, Yuhuangding Hospital, Yantai, 264000 Shandong China.
Lihui SunRegenerative Medicine Research Center, Sichuan University West China Hospital, Chengdu, 610041 Sichuan China.
Lijun DuanDepartment of Clinical Laboratory, Yuhuangding Hospital, Yantai, 264000 Shandong China.
Qing ZhengDepartment of Clinical Laboratory, Yuhuangding Hospital, Yantai, 264000 Shandong China.
Xuejun HuMedical School, Dalian University, Dalian, 116622 Liaoning China.
Yuhuangding Hospital · CNDalian University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human C-reactive protein (CRP), a classical human acute-phase plasma protein, is not only a sensitive systemic inflammatory marker but also an independent risk predictor of cardiovascular diseases. However, existing heterologous expression systems for expressing CRP is not efficient and cost-effective for large-scale industrial production of CRP to meet the growing market demand for CRP. This study aims to improve the secretion of recombinant CRP by

Indexed as

Carbon sourceC-reactive proteinPichia pastorisPromoterSecretory expressionSignal peptide

Identifiers

PMID28868218
PMCPMC5574733
OpenAlexW2753087195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.