Evidence map›Paper›PMID 28868209›Full record

ArticleJournal of clinical toxicology2017

Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion.

Matthew Brenner, Sarah M Azer, Kyung-Jin Oh, Chang Hoon Han, Jangwoen Lee, Sari B Mahon, Xiaohua Du, David Mukai, Tanya Burney, Mayer Saidian and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Efficacy of oral administration of sodium thiosulfate in a large, swine model of oral cyanide toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021
    Article
  4. Article
  5. Characterization of a Swine (Comparative medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Matthew BrennerBeckman Laser Institute, University of California, Irvine, California, USA.
Sarah M AzerBeckman Laser Institute, University of California, Irvine, California, USA.
Kyung-Jin OhDepartment of Urology, Chonnam National University Medical School, South Korea.
Chang Hoon HanDepartment of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang-si, Geonggi-do, South Korea.
Jangwoen LeeBeckman Laser Institute, University of California, Irvine, California, USA.
Sari B MahonBeckman Laser Institute, University of California, Irvine, California, USA.
Xiaohua DuPulmonary Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
David MukaiBeckman Laser Institute, University of California, Irvine, California, USA.
Tanya BurneyBeckman Laser Institute, University of California, Irvine, California, USA.
Mayer SaidianBeckman Laser Institute, University of California, Irvine, California, USA.
Adriano ChanDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Derek I StrakerDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Vikhyat S BebartaDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Gerry R BossDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
University of California, Irvine · USUniversity of California San Diego · USBeckman Laser Institute and Medical Clinic · USChonnam National University Hospital · KRFirst Affiliated Hospital of Kunming Medical University · CNNational Health Insurance Service · KRUniversity of Colorado Denver · US

Funding

Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying AgentU01NS058030 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2006 to 2017
$7.3M
ScientificU54NS063718 · NINDS · UNIVERSITY OF MINNESOTA · PI PATTERSON, STEVEN E · 2008 to 2011
$3.4M
NINDS NIH HHS U01 NS058030NINDS NIH HHS U54 NS063718
6 · The paper itself

Abstract

objectiveAccidental or intentional cyanide ingestion is an-ever present danger. Rapidly acting, safe, inexpensive oral cyanide antidotes are needed that can neutralize large gastrointestinal cyanide reservoirs. Since humans cannot be exposed to cyanide experimentally, we studied oral cyanide poisoning in rabbits, testing oral sodium thiosulfate with and without gastric alkalization.

settingUniversity research laboratory. SUBJECTS: New Zealand white rabbits.

interventionsSeven animal groups studied; Groups 1-5 received high dose oral NaCN (50 mg, >LD100) and were treated immediately with oral ( MEASUREMENTS AND MAIN

resultsAll animals in the high dose NaCN group receiving oral saline or glycine died very rapidly, with a trend towards delayed death in glycine-treated animals; saline

conclusionsOral sodium thiosulfate with gastric alkalization rescued animals from lethal doses of ingested cyanide. The combination of oral glycine and sodium thiosulfate may have potential for treating high dose acute cyanide ingestion and merits further investigation. The combination of systemic and oral therapy may provide further options.

Indexed as

Continuous wave near infrared spectroscopyGastric alkalizationGlycineOral cyanide poisoningSodium thiosulfate

Identifiers

PMID28868209
PMCPMC5578424
OpenAlexW2731684305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.