ArticleIranian journal of basic medical sciences2017
Melatonin upregulates ErbB1 and ErbB4, two primary implantation receptors, in pre-implantation mouse embryos.
Article in Iranian journal of basic medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Visible light, oxidative stress, and reproduction: The protective role of melatonin.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Assessing the role of drug interventions in the polycystic ovary syndrome model.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway.Frontiers in pharmacology · 2025Article
- Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.International journal of molecular sciences · 2024Article
- Comparative effects of a calcium chelator (BAPTA-AM) and melatonin on cryopreservation-induced oxidative stress and damage in ovarian tissue.Scientific reports · 2023Article
- Ovarian tissue cryopreservation and transplantation: a review on reactive oxygen species generation and antioxidant therapy.Cell and tissue research · 2023Review
- Placental Dysfunction in Assisted Reproductive Pregnancies: Perinatal, Neonatal and Adult Life Outcomes.International journal of molecular sciences · 2022Review
- Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression.International journal of molecular sciences · 2021Review
- Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms.International journal of molecular sciences · 2019Review
- From Implantation to Birth: Insight into Molecular Melatonin Functions.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluated the effects of melatonin on early embryo competence and the expression rate of the primary implantation receptors (ErbB1 and ErbB4). MATERIALS AND
methodsTwo-cell mouse embryos were cultured in 3 groups: simple media, melatonin-treated (10
resultsWe concluded that melatonin significantly up-regulated the ErbB1 and ErbB4 gene and protein expression, decreased intracellular ROS, increased the total antioxidant capacity, and also elevated the cell numbers in the melatonin-treated group compared with the other groups (
conclusionThe use of melatonin may be a helpful factor in improving the embryo quality and enhancing the expression of ErbB1 and ErbB4, two important implantation-related genes and proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.