ArticleThe open dentistry journal2017
On the Cellular and Molecular Mechanisms of Drug-Induced Gingival Overgrowth.
Article in The open dentistry journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Drug-induced gingival overgrowth: evaluation of an online survey.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Voclosporin-induced gingival enlargement: A case report.Clinical advances in periodontics · 2026Article
- Social media data and its potential for pharmacovigilance: a comparative analysis of reported prevalences regarding drug-induced gingival overgrowth (DIGO).Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Drug-Induced Gingival Enlargement: A Comparative Study on the Effect of Phenytoin, Gabapentin, and Cyclosporin on Gingival Fibroblast Cells.Molecular biotechnology · 2026Article
- Gingival Enlargement Induced by Orthodontic Therapy: A Systematic Review.International journal of dentistry · 2026Review
- Syndromic gingival fibromatosis associated with pathogenic variation in the voltage-gated potassium channel gene KCNH1: a case report and proposed treatment protocol.BMC oral health · 2025Article
- Novel Insights into Amlodipine-Induced Gingival Enlargement: A Clinical and Molecular Perspective.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Drug induced gingival enlargement - phenytoin: an overview and case report.Journal of surgical case reports · 2024Article
- Cyclosporine-Induced Gingival Hyperplasia in a Patient With Lichen Planopilaris: Misfortunes Never Come Singly!Cureus · 2023Article
- Calcium Channel Blockers- Induced Iatrogenic Gingival Hyperplasia: Case Series.Journal of pharmacy & bioallied sciences · 2023Article
- Drug-Induced Gingival Overgrowth-Molecular Aspects of Drug Actions.International journal of molecular sciences · 2023Review
- Review
- Identifying the focuses of hereditary gingival fibromatosis with bioinformatics strategies.American journal of translational research · 2022Article
- Drug-Induced Gingival Overgrowth: A Pilot Study on the Effect of Diphenylhydantoin and Gabapentin on Human Gingival Fibroblasts.International journal of environmental research and public health · 2020Article
- Drug-Induced Gingival Overgrowth: The Effect of Cyclosporin A and Mycophenolate Mophetil on Human Gingival Fibroblasts.Biomedicines · 2020Article
- SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth.Scientific reports · 2020Article
- Periodontal Management of Cyclosporin A-Induced Gingival Overgrowth: A Nonsurgical Approach.Case reports in dentistry · 2019Article
- The Periodontium as a Potential Cause of Orofacial Pain: A Comprehensive Review.The open dentistry journal · 2018Review
- Negligence of gingival overgrowth leading to loss of entire dentition.Journal of Indian Society of PeriodontologyArticle
- Immunohistochemical Analysis of the Role Connective Tissue Growth Factor in Drug-induced Gingival Overgrowth in Response to Phenytoin, Cyclosporine, and Nifedipine.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGingival overgrowth has been linked to multiple factors such as adverse drug effects, inflammation, neoplastic processes, and hereditary gingival fibromatosis. Drug-induced gingival overgrowth is a well-established adverse event. In early stages, this gingival enlargement is usually located in the area of the interdental papilla. Histologically, there is an increase in the different components of the extracellular matrix.
objectiveThe aim of this manuscript is to describe and analyze the different cellular and molecular agents involved in the pathogenesis of Drug-induced gingival overgrowth.
methodA literature search of the MEDLINE/PubMed database was conducted to identify the mechanisms involved in the process of drug-induced gingival overgrowth, with the assistance of a research librarian. We present several causal hypotheses and discuss the advances in the understanding of the mechanisms that trigger this gingival alteration.
results
conclusionIndividual predisposition, tissue inflammation, and molecular changes in response to the inducing drug favor the clinical manifestation of gingival overgrowth.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.