Evidence map›Paper›PMID 28868045›Full record

ArticleFrontiers in neurology2017

Primary Blast-Induced Changes in Akt and GSK

Yushan Wang, Thomas W Sawyer, Yiu Chung Tse, Changyang Fan, Grant Hennes, Julia Barnes, Tyson Josey, Tracy Weiss, Peggy Nelson, Tak Pan Wong

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
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  7. Frontiers in cellular neuroscience · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yushan WangDefence Research and Development Canada, Suffield Research Centre, Medicine Hat, AB, Canada.
Thomas W SawyerDefence Research and Development Canada, Suffield Research Centre, Medicine Hat, AB, Canada.
Yiu Chung TseDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Changyang FanDefence Research and Development Canada, Suffield Research Centre, Medicine Hat, AB, Canada.
Grant HennesDefence Research and Development Canada, Suffield Research Centre, Medicine Hat, AB, Canada.
Julia BarnesDefence Research and Development Canada, Suffield Research Centre, Medicine Hat, AB, Canada.
Tyson JoseyDefence Research and Development Canada, Suffield Research Centre, Medicine Hat, AB, Canada.
Tracy WeissDefence Research and Development Canada, Suffield Research Centre, Medicine Hat, AB, Canada.
Peggy NelsonDefence Research and Development Canada, Suffield Research Centre, Medicine Hat, AB, Canada.
Tak Pan WongDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Defence Research and Development Canada · CAMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) due to blast from improvised explosive devices has been a leading cause of morbidity and mortality in recent conflicts in Iraq and Afghanistan. However, the mechanisms of primary blast-induced TBI are not well understood. The Akt signal transduction pathway has been implicated in various brain pathologies including TBI. In the present study, the effects of simulated primary blast waves on the phosphorylation status of Akt and its downstream effector kinase, glycogen synthase kinase 3β (GSK

Indexed as

AktneurotraumaN-methyl-d-aspartate receptorprimary blasttraumatic brain injury

Identifiers

PMID28868045
PMCPMC5563325
OpenAlexW2745937044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.