Evidence map›Paper›PMID 28867969›Full record

ArticleGastroenterology & hepatology2017

An Overview of Achalasia and Its Subtypes.

Dhyanesh A Patel, Brian M Lappas, Michael F Vaezi

Open access · greenAbstract read
In one paragraph

Article in Gastroenterology & hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Peroral endoscopic myotomy compared to laparoscopic Heller myotomy and pneumatic dilation in the treatment of achalasia: a systematic review.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024
    Pooled it
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  4. Nutrition in achalasia cardia-A neglected frontier.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Article
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  9. What goes down may come up: regurgitative behaviors and their underlying gut-brain axes-insights from genetic models and related pathologies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
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  15. Optimizing achalasia diagnosis in the era of high-resolution manometry: A Pakistani perspective.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Article
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  19. Focus on Achalasia in the Omics Era.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dhyanesh A PatelDr Patel is a gastroenterology fellow in the Division of Gastroenterology, Hepatology and Nutrition; Dr Lappas is an internal medicine resident in the Department of Internal Medicine; and Dr Vaezi is a professor of medicine in the Division of Gastroenterology, Hepatology and Nutrition at Vanderbilt University Medical Center in Nashville, Tennessee.
Brian M LappasDr Patel is a gastroenterology fellow in the Division of Gastroenterology, Hepatology and Nutrition; Dr Lappas is an internal medicine resident in the Department of Internal Medicine; and Dr Vaezi is a professor of medicine in the Division of Gastroenterology, Hepatology and Nutrition at Vanderbilt University Medical Center in Nashville, Tennessee.
Michael F VaeziDr Patel is a gastroenterology fellow in the Division of Gastroenterology, Hepatology and Nutrition; Dr Lappas is an internal medicine resident in the Department of Internal Medicine; and Dr Vaezi is a professor of medicine in the Division of Gastroenterology, Hepatology and Nutrition at Vanderbilt University Medical Center in Nashville, Tennessee.
Vanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Achalasia is one of the most studied esophageal motility disorders. However, the pathophysiology and reasons that patients develop achalasia are still unclear. Patients often present with dysphagia to solids and liquids, regurgitation, and varying degrees of weight loss. There is significant latency prior to diagnosis, which can have nutritional implications. The diagnosis is suspected based on clinical history and confirmed by esophageal high-resolution manometry testing. Esophagogastroduodenoscopy is necessary to rule out potential malignancy that can mimic achalasia. Recent data presented in abstract form suggest that patients with type II achalasia may be most likely, and patients with type III achalasia may be least likely, to report weight loss compared to patients with type I achalasia. Although achalasia cannot be permanently cured, palliation of symptoms is possible in over 90% of patients with the treatment modalities currently available (pneumatic dilation, Heller myotomy, or peroral endoscopic myotomy). This article reviews the clinical presentation, diagnosis, and management options in patients with achalasia, as well as potential insights into histopathologic differences and nutritional implications of the subtypes of achalasia.

Indexed as

Achalasiahistopathologynutritionweight loss

Identifiers

PMID28867969
PMCPMC5572971
OpenAlexW2977955941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.