ArticleAnnals of neurosciences2017
Estrous Cycle Phase-Dependent Changes in Anxiety- and Depression-Like Profiles in the Late Adolescent Wistar-Kyoto Rat.
Article in Annals of neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Divergent behavioral strategies in Wistar and Wistar-Kyoto rats in a naturalistic task reveal mood disorder phenotypes.iScience · 2026Article
- Differential Effects of Oleoyl Serine and HU-910 on Anxiety-like and Depression-like Behaviors in Male and Female WKY Rats.International journal of molecular sciences · 2026Article
- Genistein Reduces Anxiety-like Behavior During Metestrus-Diestrus Phase Without Changing Estradiol or Progesterone Levels in Wistar Rats.Metabolites · 2025Article
- High-fat Diet Coupled with Aerobic Exercise Has a Sexually Dimorphic Effect on the Biochemical Profile and Anxiety-like Behaviour of Adolescent Wistar Rats.Annals of neurosciences · 2025Article
- Validation of Wistar-Kyoto rats kept in solitary housing as an animal model for depression using voxel-based morphometry.Scientific reports · 2024Article
- Shifts in naturalistic behaviors induced by early social isolation stress are associated with adult binge-like eating in female rats.Frontiers in behavioral neuroscience · 2024Article
- The mixed legacy of the rat estrous cycle.Biology of sex differences · 2023Article
- The Track-by-Day Method for Monitoring the Rodent Estrous Cycle.Current protocols · 2023Article
- Sex differences in chronic pain-induced mental disorders: Mechanisms of cerebral circuitry.Frontiers in molecular neuroscience · 2023Review
- What Pre-clinical Rat Models Can Tell Us About Anxiety Across the Menstrual Cycle in Healthy and Clinically Anxious Humans.Current psychiatry reports · 2022Review
- Estrogen, the Peripheral Immune System and Major Depression - A Reproductive Lifespan Perspective.Frontiers in behavioral neuroscience · 2022Review
- Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Effects of subanesthetic intravenous ketamine infusion on neuroplasticity-related proteins in male and female Sprague-Dawley rats.IBRO neuroscience reports · 2021Article
- Contribution of AMPA Receptor-Mediated LTD in LA/BLA-CeA Pathway to Comorbid Aversive and Depressive Symptoms in Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Effect of Estrous Cycle on Behavior of Females in Rodent Tests of Anxiety.Frontiers in psychiatry · 2021Review
- Fluoxetine effects on behavior and adult hippocampal neurogenesis in female C57BL/6J mice across the estrous cycle.Psychopharmacology · 2020Article
- Maternal stressors and the developmental origins of neuropsychiatric risk.Frontiers in neuroendocrinology · 2020Review
- The Stage of the Estrus Cycle Is Critical for Interpretation of Female Mouse Social Interaction Behavior.Frontiers in behavioral neuroscience · 2020Article
- Exposure to di-(2-ethylhexyl) phthalate transgenerationally alters anxiety-like behavior and amygdala gene expression in adult male and female mice.Physiology & behavior · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression often manifests during adolescence when the development and networking of social and emotional brain areas is being influenced by hormones. The Wistar Kyoto (WKY) rat has been proposed as an animal model of adolescent depression with various face, construct, and predictive validities for clinical depression having been established. PURPOSE: The influence of the estrous cycle on anxiety- and depression-like behaviors in female adolescents may be tested out further using this model.
methodsFemale adolescent WKY rats were tested for anxiety- and depression-like behaviors in the elevated plus maze and forced swim test (FST) during different phases of the estrous cycle with inbred, age-, and phase-matched Wistar rats as controls.
resultsWistars in proestrus-estrus demonstrated reduced anxiety levels. WKY also demonstrated increased open arm time and entries and closed arm time, but less than Wistars, and as closed arm entries remained unaffected, it did not translate into a lowering of the anxiety levels. Risk taking and risk assessment behaviors were not affected by estrous phases in WKY, though exploratory behavior was reduced in proestrus-estrus. In Wistars, increased risk taking and decreased risk assessment behaviors were observed during proestrus-estrus. Increased immobility in the FST, indicative of learned helplessness was not influenced by phase in the WKY, which was at variance with Wistars that demonstrated phase-specific differences.
conclusionResults indicate a masking effect of indicative hormones in this putative model of adolescent depression, with implications for an unravelling of the steroid milieu in predisposed adolescent depression and for taking phase-specific time windows into account for therapeutic interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.