ArticleDevelopmental cell2017
Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility.
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Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
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Who cites it
81 citing papers in PubMed, 129 citations in OpenAlex.
- High-resolution CRISPR/Cas9 screens identify PAK2 as a suppressor of macrophage proliferation.bioRxiv : the preprint server for biology · 2026Article
- Arp2/3 complex and β1 integrin drive an invasive front through extracellular matrix adaptation in pancreatic cancer.International journal of cancer · 2026Article
- Quantitative analysis of fibroblast migration reveals migratory states characterized by force generation, cell shape and motion.bioRxiv : the preprint server for biology · 2026Article
- Article
- Super-Resolution Structured Illumination Microscopy to Study Endocytosis and Cellular Nanoparticle Uptake.ACS nano · 2026Review
- The Arp2/3 complex controls the development of homeostatic microglia.EMBO reports · 2026Article
- The Arp2/3 complex is required for in situ haptotactic response of microglia to iC3b.EMBO reports · 2026Article
- ARPC2 Promotes Pulmonary Fibrosis by Regulating MRTFA Activity Independent of the Canonical ARP2/3 Complex.International journal of molecular sciences · 2026Article
- Control of microglial dynamics by the Arp2/3 complex and the autism- and schizophrenia-associated protein CYFIP1.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Actin-membrane interface stress regulates Arp2/3-branched actin density during lamellipodial protrusion.bioRxiv : the preprint server for biology · 2026Article
- Arp2/3 complex contributes to the actin-dependent uptake of Aspergillus terreus conidia by alveolar epithelial cells.PloS one · 2026Article
- Cytoskeleton-mediated autophagy regulation in neuroimmune contexts: molecular mechanisms and functional perspectives.Frontiers in immunology · 2026Review
- Targeting efferocytosis for tissue regeneration: From microenvironment reprogramming to clinical translation.Theranostics · 2026Review
- Biomechanical signaling of cytoskeleton and membrane reorganization in tumor immune chemotactic migration.Theranostics · 2026Review
- Please inhibit responsibly: Natural and synthetic actin toxins as useful tools in cell biology.Molecular biology of the cell · 2025Review
- Physical confinement and phagocytic uptake induce persistent cell migration.Biology open · 2025Article
- Macrophages migrate persistently and directionally upon entering 2D confinement in the presence of extracellular matrix.Biology open · 2025Article
- Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Phagocytosis at a glance.Journal of cell science · 2025Review
- The Arp2/3 complex is required forbioRxiv : the preprint server for biology · 2025Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Jeremy D RottyUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Hailey E BrightonUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Stephanie L CraigUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sreeja B AsokanUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ning ChengUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Oral Biology Curriculum, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jenny P TingUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Oral Biology Curriculum, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
James E BearUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: jbear@email.unc.edu.
University of North Carolina at Chapel Hill · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MMolecular and Functional Analysis of NLR Family MembersR01AI029564 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jenny P Ting · 1991 to 2026
$6.0MMultiscale Modeling of Wound HealingU01EB018816 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HAUGH, JASON M. · 2014 to 2021
$4.0MPlexin-A1: Regulation by CIITA and Immunologic FunctionR37AI029564 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TING, JENNY P · 2008 to 2017
$3.8MThe role of the Arp2/3 complex in cellular actin dynamicsR01GM111557 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BEAR, JAMES E · 2014 to 2018
$1.5MMechanisms of mesenchymal chemotaxisR01GM110155 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BEAR, JAMES E, HAUGH, JASON M. · 2014 to 2017
$1.4MPlexin-A1: Regulation by CIITA and immunologic functionR56AI029564 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TING, JENNY P.Y. · 2007 to 2007
$363kNCI NIH HHS P30 CA016086NIAID NIH HHS R01 AI029564NIAID NIH HHS R37 AI029564NIAID NIH HHS R56 AI029564NIBIB NIH HHS U01 EB018816NIGMS NIH HHS R01 GM110155NIGMS NIH HHS R01 GM111557
Abstract
The Arp2/3 complex nucleates branched actin, forming networks involved in lamellipodial protrusion, phagocytosis, and cell adhesion. We derived primary bone marrow macrophages lacking Arp2/3 complex (Arpc2
Indexed as
Cell MovementPhagocytosisActin-Related Protein 2-3 ComplexActinsAnimalsCell ShapeChemokine CX3CL1ChemotaxisColony-Stimulating FactorsFemaleFibronectinsIntegrinsLigandsMacrophage-1 AntigenMacrophagesMaleActin-Related Protein 2-3 ComplexActinsChemokine CX3CL1Colony-Stimulating FactorsFibronectinsIntegrinsLigandsMacrophage-1 AntigenMyosin Heavy ChainsReceptors, FcReceptors, G-Protein-CoupledactinArp2/3directed migrationintegrinmacrophagephagocytosis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.