Evidence map›Paper›PMID 28867375›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2017

Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis.

Abraham R Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R Edelman

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05973994 (Shockwave Induced Attenuation of Calcified Plaques Quantified With OCT), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05973994 unknown statusnot on this mapstarted 2022, after this paper: background citation

Shockwave Induced Attenuation of Calcified Plaques Quantified With OCT

Typeobservational_patient_registrySponsorUniversity of Rome Tor VergataRan2022 to 2024Enrolled30ConditionsCoronary Artery CalcificationArmsintravascular lithotripsy with Shockwave coronary system
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Three-Year Sustained Clinical Efficacy of Drug-Coated Balloon Angioplasty in a Real-World Femoropopliteal Cohort.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2020
    Trial
  5. Review
  6. Observational
  7. Intravascular lithotripsy of the femoropopliteal arteries: analysis of a prospective two-center pilot study.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026
    Article
  8. In-hospital outcomes of intravascular lithotripsy compared to rotational atherectomy and cutting/scoring balloon angioplasty.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Outcomes of coronary intravascular lithotripsy for the treatment of calcified nodules: a pooled analysis of the Disrupt CAD studies.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Endovascular Drug Delivery.Life (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Abraham R TzafririCBSET Inc., 500 Shire Way, Lexington, MA, USA; IMES, MIT, 77 Massachusetts Avenue, Cambridge, MA, USA. Electronic address: ramitz@mit.edu.
Fernando Garcia-PoliteCBSET Inc., 500 Shire Way, Lexington, MA, USA; IMES, MIT, 77 Massachusetts Avenue, Cambridge, MA, USA.
Brett ZaniCBSET Inc., 500 Shire Way, Lexington, MA, USA.
James StanleyCBSET Inc., 500 Shire Way, Lexington, MA, USA.
Benny MurajCBSET Inc., 500 Shire Way, Lexington, MA, USA.
Jennifer KnutsonCBSET Inc., 500 Shire Way, Lexington, MA, USA; Cardiovascular Systems, Inc., 1225 Old Hwy 8NW, Saint Paul, MN, USA.
Robert KohlerCardiovascular Systems, Inc., 1225 Old Hwy 8NW, Saint Paul, MN, USA.
Peter MarkhamCBSET Inc., 500 Shire Way, Lexington, MA, USA.
Alexander NikanorovCardiovascular Systems, Inc., 1225 Old Hwy 8NW, Saint Paul, MN, USA.
Elazer R EdelmanIMES, MIT, 77 Massachusetts Avenue, Cambridge, MA, USA; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Cardiovascular Systems (United States) · USIIT@MIT · US

Funding

Vascular Drug Delivery - Supplement for EquipmentR01GM049039 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EDELMAN, ELAZER R · 1994 to 2019
$8.9M
NIGMS NIH HHS R01 GM049039
6 · The paper itself

Abstract

backgroundCalcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD).

objectivesWe evaluated the effects of orbital atherectomy on intraluminal paclitaxel delivery to human peripheral arteries with substantial calcified plaque.

methodsDiagnostic angiography and 3-D rotational imaging of five fresh human lower limbs revealed calcification in all main arteries. The proximal or distal segment of each artery was treated using an orbital atherectomy system (OAS) under simulated blood flow and fluoroscopy. Explanted arterial segments underwent either histomorphometric assessment of effect or tracking of

resultsLesion composition affected paclitaxel absorption and distribution in cadaveric human peripheral arteries. Pretreatment imaging calcium scores in control femoropopliteal arterial segments correlated with a log-linear decline in the bulk absorption rate-constant of

conclusionsThese data illustrate that calcified plaque limited intravascular drug delivery, and controlled OAS treatment of calcific plaques resulted in greater drug permeability and improved adjunct drug delivery to diseased arteries.

Indexed as

Antineoplastic Agents, PhytogenicAtherosclerosisBiological TransportCalcinosisHumansLower ExtremityPaclitaxelPeripheral Arterial DiseasePlaque, AtheroscleroticAntineoplastic Agents, PhytogenicPaclitaxelAtherectomyDrug coated balloonsDrug eluting stentsOrbital atherectomy, calcified plaquePaclitaxelPeripheral artery disease

Identifiers

PMID28867375
PMCPMC5955709
OpenAlexW2751413124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.