ArticleCurrent biology : CB2017
Lesions of the Head Direction Cell System Increase Hippocampal Place Field Repetition.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Months-long stability of the head-direction system.Nature · 2026Article
- Continuous attractor dynamics in spatial navigation: from population geometry to flexible computation.Frontiers in neuroscience · 2026Review
- Article
- Electrophysiological signatures of veridical head direction in humans.Nature human behaviour · 2024Article
- A configural context signal simultaneously but separably drives positioning and orientation of hippocampal place fields.Hippocampus · 2024Article
- Interactions between rodent visual and spatial systems during navigation.Nature reviews. Neuroscience · 2023Review
- Cortical Integration of Vestibular and Visual Cues for Navigation, Visual Processing, and Perception.Annual review of neuroscience · 2023Review
- Flexible cue anchoring strategies enable stable head direction coding in both sighted and blind animals.Nature communications · 2022Article
- Time to retire the serial Papez circuit: Implications for space, memory, and attention.Neuroscience and biobehavioral reviews · 2022Review
- A Subdural Bioelectronic Implant to Record Electrical Activity from the Spinal Cord in Freely Moving Rats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Sharp Tuning of Head Direction and Angular Head Velocity Cells in the Somatosensory Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Visual imagination and cognitive mapping of a virtual building.Journal of navigation · 2022Article
- Entorhinal-hippocampal interactions lead to globally coherent representations of space.Current research in neurobiology · 2022Review
- The stimulus control of local enclosures and barriers over head direction and place cell spatial firing.Brain and behavior · 2021Article
- Hippocampal place cells encode global location but not connectivity in a complex space.Current biology : CB · 2021Article
- Time to put the mammillothalamic pathway into context.Neuroscience and biobehavioral reviews · 2021Review
- Home, head direction stability, and grid cell distortion.Journal of neurophysiology · 2020Article
- Dissociable Networks of the Lateral/Medial Mammillary Body in the Human Brain.Frontiers in human neuroscience · 2020Article
- Why Isn't the Head Direction System Necessary for Direction? Lessons From the Lateral Mammillary Nuclei.Frontiers in neural circuits · 2019Article
- Three-dimensional tuning of head direction cells in rats.Journal of neurophysiology · 2019Article
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A central tenet of systems neuroscience is that the mammalian hippocampus provides a cognitive map of the environment. This view is supported by the finding of place cells, neurons whose firing is tuned to specific locations in an animal's environment, within this brain region. Recent work, however, has shown that these cells repeat their firing fields across visually identical maze compartments [1, 2]. This repetition is not observed if these compartments face different directions, suggesting that place cells use a directional input to differentiate otherwise similar local environments [3, 4]. A clear candidate for this input is the head direction cell system. To test this, we disrupted the head direction cell system by lesioning the lateral mammillary nuclei and then recorded place cells as rats explored multiple, connected compartments, oriented in the same or in different directions. As shown previously, we found that place cells in control animals exhibited repeated fields in compartments arranged in parallel, but not in compartments facing different directions. In contrast, the place cells of animals with lesions of the head direction cell system exhibited repeating fields in both conditions. Thus, directional information provided by the head direction cell system appears essential for the angular disambiguation by place cells of visually identical compartments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.