ArticleCurrent biology : CB2017
Collective Growth in a Small Cell Network.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Complementary volume electron microscopy-based approaches reveal ultrastructural changes in germline intercellular bridges.Journal of cell science · 2026Article
- Bridges under construction: the dynamics of ring canal expansion during Drosophila oogenesis.Developmental biology · 2026Review
- Lineage-based scaling of germline intercellular bridges during oogenesis.Development (Cambridge, England) · 2024Article
- Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila.Current biology : CB · 2024Article
- Article
- Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability inbioRxiv : the preprint server for biology · 2023Article
- Cell-based allometry: an approach for evaluation of complexity in morphogenesis.Quantitative biology (Beijing, China) · 2023Article
- Go with the flow - bulk transport by molecular motors.Journal of cell science · 2023Review
- Live Imaging of Nurse Cell Behavior in Late Stages of Drosophila Oogenesis.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The Nuclear-to-Cytoplasmic Ratio: Coupling DNA Content to Cell Size, Cell Cycle, and Biosynthetic Capacity.Annual review of genetics · 2022Review
- Quantitative models for building and growing fated small cell networks.Interface focus · 2022Review
- A topological look into the evolution of developmental programs.Biophysical journal · 2021Article
- Size scaling in collective cell growth.Development (Cambridge, England) · 2021Article
- Gatekeeper function for Short stop at the ring canals of the Drosophila ovary.Current biology : CB · 2021Article
- Elimination of nurse cell nuclei that shuttle into oocytes during oogenesis.The Journal of cell biology · 2021Article
- Coupled oscillators coordinate collective germline growth.Developmental cell · 2021Article
- Dynamics of hydraulic and contractile wave-mediated fluid transport duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Gradient in cytoplasmic pressure in germline cells controls overlying epithelial cell morphogenesis.PLoS biology · 2020Article
- Testing Models of mRNA Localization Reveals Robustness Regulated by Reducing Transport between Cells.Biophysical journal · 2019Article
- Entropic effects in cell lineage tree packings.Nature physics · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Theoretical studies suggest that many of the emergent properties associated with multicellular systems arise already in small networks [1, 2]. However, the number of experimental models that can be used to explore collective dynamics in well-defined cell networks is still very limited. Here we focus on collective cell behavior in the female germline cyst in Drosophila melanogaster, a stereotypically wired network of 16 cells that grows by ∼4 orders of magnitude with unequal distribution of volume among its constituents. We quantify multicellular growth with single-cell resolution and show that proximity to the oocyte, as defined on the network, is the principal factor that determines cell size; consequently, cells grow in groups. To rationalize this emergent pattern of cell sizes, we propose a tractable mathematical model that depends on intercellular transport on a cell lineage tree. In addition to correctly predicting the divergent pattern of cell sizes, this model reveals allometric growth of cells within the network, an emergent property of this system and a feature commonly associated with differential growth on an organismal scale [3].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.