Evidence map›Paper›PMID 28866728›Full record

ReviewPflugers Archiv : European journal of physiology2018

Electrochemical measurement of quantal exocytosis using microchips.

Kevin D Gillis, Xin A Liu, Andrea Marcantoni, Valentina Carabelli

Abstract readReview
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kevin D GillisDepartment of Bioengineering, University of Missouri, Columbia, MO, USA. gillisk@missouri.edu.
Xin A LiuDalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA.
Andrea MarcantoniDepartment of Drug Science and "NIS" Inter-departmental Centre, University of Torino, Torino, Italy.
Valentina CarabelliDepartment of Drug Science and "NIS" Inter-departmental Centre, University of Torino, Torino, Italy.

Funding

Microchip devices to assay quantal exocytosisR01NS048826 · NINDS · UNIVERSITY OF MISSOURI-COLUMBIA · PI GILLIS, KEVIN D · 2004 to 2009
$2.8M
Scalable sensor array platform for analysis of quantal transmitter release eventsR01MH095046 · NIMH · CORNELL UNIVERSITY · PI LINDAU, MANFRED · 2011 to 2014
$1.5M
Development of a prototype system for assaying exocytosis from individual cells using using transparent microelectrode arraysR44MH096650 · NIMH · EXOCYTRONICS, LLC · PI GILLIS, KEVIN D, GU, LI-QUN (ANDREW) · 2015 to 2017
$1.5M
Scalable amperometric microchip array for high-throughput screening of small molecules, peptides or genetic perturbations for modulation of quantal transmitter releaseR43MH109212 · NIMH · EXOCYTRONICS, LLC · PI LINDAU, MANFRED, LIU, XIN ALICE · 2016 to 2017
$869k
Development of a prototype system for assaying exocytosis from individual cellsR43MH096650 · NIMH · EXOCYTRONICS, LLC · PI GILLIS, KEVIN D, LIU, XIN ALICE · 2011 to 2012
$667k
Italian Miur 2015 FNWP34NIMH NIH HHS R01 MH095046NIMH NIH HHS R01MH095046NIMH NIH HHS R43 MH096650NIMH NIH HHS R43 MH109212NIMH NIH HHS R44 MH096650NIMH NIH HHS R44MH096650NINDS NIH HHS R01 NS048826NINDS NIH HHS R01NS048826San Paolo Foundation CSTO 165284
6 · The paper itself

Abstract

Carbon-fiber electrodes (CFEs) are the gold standard for quantifying the release of oxidizable neurotransmitters from single vesicles and single cells. Over the last 15 years, microfabricated devices have emerged as alternatives to CFEs that offer the possibility of higher throughput, subcellular spatial resolution of exocytosis, and integration with other techniques for probing exocytosis including microfluidic cell handling and solution exchange, optical imaging and stimulation, and electrophysiological recording and stimulation. Here we review progress in developing electrochemical electrode devices capable of resolving quantal exocytosis that are fabricated using photolithography.

Indexed as

ExocytosisLab-On-A-Chip DevicesAnimalsCarbonCarbon FiberChromaffin CellsElectrochemical TechniquesHumansMicroelectrodesMicrofluidic Analytical TechniquesOptical ImagingCarbonCarbon FiberbioMEMSMulti-electrode arrays

Identifiers

PMID28866728
PMCPMC5750118

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.